Title:
COMPOUNDS THAT MODULATE THE ACTIVITY OF PTP-1B AND TC-PTP
Document Type and Number:
WIPO Patent Application WO2003073987
Kind Code:
A3
Abstract:
The present invention relates to a new and improved method for treating diabetes and or its associated complications by modulating the activity of protein tryosin phosphatase 1B ("PTP-1B"). The inventive compounds modulate the activity PTP-1B by binding to a novel binding site referred herein as the PTP-1B exosite that is distal to the active site of PTP-1B. The present invention also relates to a new and improved method of treating immune system disorders by modulating the activity of T-cell protein tyrosine phosphatase ("TC-PTP"). The inventive compound modulate the activity of TC-PTP by binding to a novel binding site referred herein as the TC-PTP exosite that is distal to the active site of PTP-1B.
Inventors:
BARR KENNETH (US)
FAHR BRUCE (US)
HANSEN STIG (US)
WIESMANN CHRISTIAN (US)
FAHR BRUCE (US)
HANSEN STIG (US)
WIESMANN CHRISTIAN (US)
Application Number:
PCT/US2003/005950
Publication Date:
March 31, 2005
Filing Date:
February 26, 2003
Export Citation:
Assignee:
SUNESIS PHARMACEUTICALS INC (US)
BARR KENNETH (US)
FAHR BRUCE (US)
HANSEN STIG (US)
WIESMANN CHRISTIAN (US)
BARR KENNETH (US)
FAHR BRUCE (US)
HANSEN STIG (US)
WIESMANN CHRISTIAN (US)
International Classes:
C12N15/09; A61K31/343; A61K31/635; A61K45/00; A61P3/04; A61P3/10; A61P9/00; A61P13/12; A61P27/02; A61P43/00; C07D307/80; C07D405/12; C07D417/12; C12Q1/42; (IPC1-7): A61K31/343; C07D307/80
Foreign References:
| US6407243B1 | 2002-06-18 |
Other References:
See also references of EP 1534264A4
Download PDF: