Title:
COMPOUNDS THAT PARTICIPATE IN COOPERATIVE BINDING AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/132597
Kind Code:
A8
Abstract:
The disclosure features macrocyclic compounds, alone and in combination with other therapeutic agents, as well as pharmaceutical compositions and protein complexes thereof, capable of modulating biological processes including RAS and RAS-RAF inhibition, and their uses in the treatment of cancers.
Inventors:
JIN MEIZHONG (US)
PERL NICHOLAS (US)
KOHLMANN ANNA (US)
YIN NING (US)
LOWE JASON T (US)
AHN JAE YOUNG (US)
MULVIHILL MARK JOSEPH (US)
KOLTUN ELENA S (US)
GILL ADRIAN L (US)
PERL NICHOLAS (US)
KOHLMANN ANNA (US)
YIN NING (US)
LOWE JASON T (US)
AHN JAE YOUNG (US)
MULVIHILL MARK JOSEPH (US)
KOLTUN ELENA S (US)
GILL ADRIAN L (US)
Application Number:
PCT/US2019/068100
Publication Date:
July 16, 2020
Filing Date:
December 20, 2019
Export Citation:
Assignee:
REVOLUTION MEDICINES INC (US)
International Classes:
A61K31/504; A61K38/12; C07K5/02
Attorney, Agent or Firm:
BELLIVEAU, Michael J. (US)
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