Title:
COMPOUNDS FOR THE TREATMENT OF DISEASES CAUSED BY OXALATE ACCUMULATION
Document Type and Number:
WIPO Patent Application WO/2018/162785
Kind Code:
A3
Abstract:
The present invention relates to the use of derivatives of salicylic acid for the treatment of diseases or conditions linked to GO and/or PRODH2 enzyme activity, in particular diseases linked to an excess of oxalate, and for the treatment of patients with renal insufficiency (uremia or azotaemia) receiving haemodialysis or peritoneal dialysis, in particular patients treated with ascorbic acid (vitamin C), which is metabolised to oxalate, or patients with fibromyalgia and vulvar pain.
Inventors:
DÍAZ GAVILÁN MÓNICA (ES)
GÓMEZ VIDAL JOSÉ ANTONIO (ES)
MOYA GARZÓN MARÍA DOLORES (ES)
SALIDO RUIZ EDUARDO (ES)
MARTÍN HIGUERAS CRISTINA (ES)
FERNANDES MIGUEL XAVIER (ES)
GÓMEZ VIDAL JOSÉ ANTONIO (ES)
MOYA GARZÓN MARÍA DOLORES (ES)
SALIDO RUIZ EDUARDO (ES)
MARTÍN HIGUERAS CRISTINA (ES)
FERNANDES MIGUEL XAVIER (ES)
Application Number:
PCT/ES2018/070184
Publication Date:
November 08, 2018
Filing Date:
March 12, 2018
Export Citation:
Assignee:
UNIV GRANADA (ES)
UNIV LA LAGUNA (ES)
UNIV LA LAGUNA (ES)
International Classes:
A61K31/625; A61P13/04
Other References:
FARGUE SONIA ET AL.: "Multiple mechanisms of action of pyridoxine in primary hyperoxaluria type 1", BIOCHIMICA ET BIOPHYSICA ACTA OCT 2013, vol. 1832, no. 10, 30 September 2013 (2013-09-30), pages 1776 - 1783, XP055548543, ISSN: 0925-4439
FARGUE SONIA ET AL.: "Effects of alanine:glyoxylate aminotransferase variants and pyridoxine sensitivity on oxalate metabolism in a cell -based cytotoxicity assay", BIOCHIMICA ET BIOPHYSICA ACTA . MOLECULAR BASIS OF DISEASE, vol. 1862, no. 6, 6 February 2016 (2016-02-06), AMSTERDAM, NL, pages 1055 - 1062, XP055548550, ISSN: 0925-4439
LORENZO VICTOR ET AL.: "Primary hyperoxaluria", NEFROLOGIA: PUBLICATION OFICIAL DE LA SOCIEDAD ESPANOLA NEFROLOGIA SPAIN, vol. 34, no. 3, 21 May 2014 (2014-05-21), pages 398 - 412, XP055548556, ISSN: 1989-2284, Retrieved from the Internet
CRISTINA MARTIN-HIGUERAS ET AL.: "Glycolate Oxidase Is a Safe and Efficient Target for Substrate Reduction Therapy in a Mouse Model of Primary Hyperoxaluria Type I", MOLECULAR THERAPY : THE JOURNAL OF THE AMERICAN SOCIETY OF GENE THERAPY, vol. 24, no. 4, 1 April 2016 (2016-04-01), US, pages 719 - 725, XP055307346, ISSN: 1525-0016, Retrieved from the Internet
CANDICE B SUMMITT ET AL.: "Proline dehydrogenase 2 (PRODH2) is a hydroxyproline dehydrogenase (HYPDH) and molecular target for treating primary hyperoxaluria", BIOCHEMICAL JOURNAL, vol. 466, no. 2, 1 March 2015 (2015-03-01), GB, pages 273 - 281, XP055548563, ISSN: 0264-6021
STENBERG K A J ET AL.: "Three-dimensional structure of glycolate oxidase with bound active-site inhibitor", PROTEIN SCIENCE, vol. 6, 1 January 1997 (1997-01-01), US, pages 1009 - 1015, XP055548586, ISSN: 0961-8368
KLESSIG DANIEL F ET AL.: "Multiple Targets of Salicylic Acid and Its Derivatives in Plants and Animals", FRONTIERS IN IMMUNOLOGY SWITZERLAND 2016, vol. 7, 26 May 2016 (2016-05-26), pages 206, XP055548590, Retrieved from the Internet
FARGUE SONIA ET AL.: "Effects of alanine:glyoxylate aminotransferase variants and pyridoxine sensitivity on oxalate metabolism in a cell -based cytotoxicity assay", BIOCHIMICA ET BIOPHYSICA ACTA . MOLECULAR BASIS OF DISEASE, vol. 1862, no. 6, 6 February 2016 (2016-02-06), AMSTERDAM, NL, pages 1055 - 1062, XP055548550, ISSN: 0925-4439
LORENZO VICTOR ET AL.: "Primary hyperoxaluria", NEFROLOGIA: PUBLICATION OFICIAL DE LA SOCIEDAD ESPANOLA NEFROLOGIA SPAIN, vol. 34, no. 3, 21 May 2014 (2014-05-21), pages 398 - 412, XP055548556, ISSN: 1989-2284, Retrieved from the Internet
CRISTINA MARTIN-HIGUERAS ET AL.: "Glycolate Oxidase Is a Safe and Efficient Target for Substrate Reduction Therapy in a Mouse Model of Primary Hyperoxaluria Type I", MOLECULAR THERAPY : THE JOURNAL OF THE AMERICAN SOCIETY OF GENE THERAPY, vol. 24, no. 4, 1 April 2016 (2016-04-01), US, pages 719 - 725, XP055307346, ISSN: 1525-0016, Retrieved from the Internet
CANDICE B SUMMITT ET AL.: "Proline dehydrogenase 2 (PRODH2) is a hydroxyproline dehydrogenase (HYPDH) and molecular target for treating primary hyperoxaluria", BIOCHEMICAL JOURNAL, vol. 466, no. 2, 1 March 2015 (2015-03-01), GB, pages 273 - 281, XP055548563, ISSN: 0264-6021
STENBERG K A J ET AL.: "Three-dimensional structure of glycolate oxidase with bound active-site inhibitor", PROTEIN SCIENCE, vol. 6, 1 January 1997 (1997-01-01), US, pages 1009 - 1015, XP055548586, ISSN: 0961-8368
KLESSIG DANIEL F ET AL.: "Multiple Targets of Salicylic Acid and Its Derivatives in Plants and Animals", FRONTIERS IN IMMUNOLOGY SWITZERLAND 2016, vol. 7, 26 May 2016 (2016-05-26), pages 206, XP055548590, Retrieved from the Internet
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