Title:
COMPOUNDS FOR USE AS THERAPEUTIC AGENTS AFFECTING P53 EXPRESSION AND/OR ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2012/131656
Kind Code:
A3
Abstract:
The present invention relates to compound (I) wherein R1 and R2 independently represent a hydrogen atom, a (C1-C4)alkoxy group, a fluoro(C1-C4)alkoxy group, a hydroxyl group, a benzyloxy group, a di(C1-C4)alkylamino group, a pyridyl- vinyl group, a pyrimidinyl- vinyl group, a styryl group, or a -NHCOphenyl group; R3, R4 and R5 independently represent a hydrogen atom, a (C1-C4)alkyl group, a CONHR6 group, a -CONR7R8 group, a -SO2NHR6 group, or a heteroaryl group optionally substituted by a halogen atom, a -(CH2)nNR7R8 group or a hydroxy(C1-C4)alkyl group; R6 represents a hydrogen atom, a -(CHR9)m(CH2)nNR7R8 group or a (C1-C6)alkyl group optionally substituted by a hydroxyl group; or anyone of its pharmaceutically acceptable salt, for use in a method for preventing, inhibiting or treating a disease in a patient suffering thereof, said disease involving a deregulated p53. Some of said compounds are new and also form part of the invention.
Inventors:
SCHERRER DIDIER (FR)
TAZI JAMAL (FR)
NAJMAN ROMAIN (FR)
MAHUTEAU FLORENCE (FR)
ROUX PIERRE (FR)
TAZI JAMAL (FR)
NAJMAN ROMAIN (FR)
MAHUTEAU FLORENCE (FR)
ROUX PIERRE (FR)
Application Number:
PCT/IB2012/051603
Publication Date:
November 22, 2012
Filing Date:
April 02, 2012
Export Citation:
Assignee:
SPLICOS SOC (FR)
CENTRE NAT RECH SCIENT (FR)
INST CURIE (FR)
UNIV MONTPELLIER 2 (FR)
SCHERRER DIDIER (FR)
TAZI JAMAL (FR)
NAJMAN ROMAIN (FR)
MAHUTEAU FLORENCE (FR)
ROUX PIERRE (FR)
CENTRE NAT RECH SCIENT (FR)
INST CURIE (FR)
UNIV MONTPELLIER 2 (FR)
SCHERRER DIDIER (FR)
TAZI JAMAL (FR)
NAJMAN ROMAIN (FR)
MAHUTEAU FLORENCE (FR)
ROUX PIERRE (FR)
International Classes:
A61K31/4192; A61K31/4164; A61K31/44; A61P1/16; A61P9/00; A61P21/00; A61P25/00; A61P29/00; A61P35/00; C07D213/74; C07D233/54; C07D249/06; C07D401/12
Foreign References:
| US20110053975A1 | 2011-03-03 | |||
| US3409668A | 1968-11-05 | |||
| US2671805A | 1954-03-09 | |||
| JPS5095285A | 1975-07-29 |
Other References:
NAYAK S K ET AL: "p53-Induced apoptosis and inhibitors of p53", CURRENT MEDICINAL CHEMISTRY 2009 BENTHAM SCIENCE PUBLISHERS B.V. NLD LNKD- DOI:10.2174/092986709788681976, vol. 16, no. 21, 2009, pages 2627 - 2640, XP007919173, ISSN: 0929-8673
HARDCASTLE IAN R: "Inhibitors of the MDM2-p53 interaction as anticancer drugs", DRUGS OF THE FUTURE, vol. 32, no. 10, October 2007 (2007-10-01), pages 883 - 896, XP007919174, ISSN: 0377-8282
HARDCASTLE IAN R: "Inhibitors of the MDM2-p53 interaction as anticancer drugs", DRUGS OF THE FUTURE, vol. 32, no. 10, October 2007 (2007-10-01), pages 883 - 896, XP007919174, ISSN: 0377-8282
Attorney, Agent or Firm:
LE COUPANEC, Pascale (3 rue de Penthièvre, Paris, FR)
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