Title:
COMPOUNDS FOR USE IN THE TREATMENT OF TELOMERE RELATED DISEASES AND/OR TELOMERE RELATED MEDICAL CONDITIONS
Document Type and Number:
WIPO Patent Application WO/2017/077516
Kind Code:
A3
Abstract:
The invention relates to compounds for use in the treatment of telomere related diseases and/or telomere related medical conditions, particularly wherein said telomere related diseases and/or telomere related medical conditions are cancer and cellular ageing. Particularly, herein is disclosed 37 kDa/67 kDa laminin receptor precursor/ high affinity laminin receptor (LRP/LR) and/or a fragment thereof for use in the treatment and/or prevention of cellular ageing.
Inventors:
WEISS STEFAN FRANZ THOMAS (ZA)
LETSOLO BOITELO THERESIAH (ZA)
NAIDOO KERRILYN (ZA)
OTGAAR TYRONE CHAD (ZA)
LETSOLO BOITELO THERESIAH (ZA)
NAIDOO KERRILYN (ZA)
OTGAAR TYRONE CHAD (ZA)
Application Number:
PCT/IB2016/056686
Publication Date:
September 28, 2017
Filing Date:
November 07, 2016
Export Citation:
Assignee:
UNIV JOHANNESBURG WITWATERSRAND (ZA)
International Classes:
A61K38/17; A61K39/395; A61P3/10; A61P9/10; A61P17/00; A61P17/06; A61P19/10; A61P21/00; A61P35/00; A61P37/04; A61P39/00; C07K14/705; C07K16/28; C12N15/11; C12N15/113
Domestic Patent References:
| WO1998053838A2 | 1998-12-03 | |||
| WO2004012681A2 | 2004-02-12 | |||
| WO2012054739A2 | 2012-04-26 |
Foreign References:
| US20020040001A1 | 2002-04-04 |
Other References:
NAIDOO KERRILYN ET AL: "Knock-Down of the 37kDa/67kDa Laminin Receptor LRP/LR Impedes Telomerase Activity.", PLOS ONE 2015, vol. 10, no. 11, 4 May 2015 (2015-05-04), pages e0141618, XP002768847, ISSN: 1932-6203
JOHN NELSON ET AL: "The 67 kDa laminin receptor: structure, function and role in disease", BIOSCIENCE REPORTS, vol. 28, no. 1, February 2008 (2008-02-01), pages 33, XP055071262, ISSN: 0144-8463, DOI: 10.1042/BSR20070004
BIANCA DA COSTA DIAS ET AL: "Anti-LRP/LR specific antibody IgG1-iS18 and knock-down of LRP/LR by shRNAs rescue cells from A[beta]42 induced cytotoxicity", SCIENTIFIC REPORTS, vol. 3, 19 September 2013 (2013-09-19), XP055361073, DOI: 10.1038/srep02702
KATARINA JOVANOVIC ET AL: "Novel patented therapeutic approaches targeting the 37/67 kDa laminin receptor for treatment of cancer and Alzheimer's disease", EXPERT OPINION ON THERAPEUTIC PATENTS., vol. 25, no. 5, 4 May 2015 (2015-05-04), GB, pages 567 - 582, XP055360936, ISSN: 1354-3776, DOI: 10.1517/13543776.2015.1014802
JOHN NELSON ET AL: "The 67 kDa laminin receptor: structure, function and role in disease", BIOSCIENCE REPORTS, vol. 28, no. 1, February 2008 (2008-02-01), pages 33, XP055071262, ISSN: 0144-8463, DOI: 10.1042/BSR20070004
BIANCA DA COSTA DIAS ET AL: "Anti-LRP/LR specific antibody IgG1-iS18 and knock-down of LRP/LR by shRNAs rescue cells from A[beta]42 induced cytotoxicity", SCIENTIFIC REPORTS, vol. 3, 19 September 2013 (2013-09-19), XP055361073, DOI: 10.1038/srep02702
KATARINA JOVANOVIC ET AL: "Novel patented therapeutic approaches targeting the 37/67 kDa laminin receptor for treatment of cancer and Alzheimer's disease", EXPERT OPINION ON THERAPEUTIC PATENTS., vol. 25, no. 5, 4 May 2015 (2015-05-04), GB, pages 567 - 582, XP055360936, ISSN: 1354-3776, DOI: 10.1517/13543776.2015.1014802
Attorney, Agent or Firm:
DESSINGTON & ASSOCIATES, INC. (ZA)
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