Title:
COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE
Document Type and Number:
WIPO Patent Application WO/2014/143242
Kind Code:
A8
Abstract:
The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula (I); or a pharmaceutically acceptable salt, wherein the variables R1, R2, R3, and R4 are as defined herein.
Inventors:
CHARRIER JEAN-DAMIEN (GB)
DAVIS CHRIS (GB)
DURRANT STEVEN (GB)
FRAYSSE DAMIEN (GB)
JIMENEZ JUAN-MIGUEL (GB)
KAY DAVE (GB)
KNEGTEL RONALD (GB)
O'DONNELL MICHAEL (GB)
PIERARD FRANCOISE (GB)
PINDER JOANNE (GB)
STORCK PIERRE-HENRI (GB)
TWIN HEATHER (GB)
DAVIS CHRIS (GB)
DURRANT STEVEN (GB)
FRAYSSE DAMIEN (GB)
JIMENEZ JUAN-MIGUEL (GB)
KAY DAVE (GB)
KNEGTEL RONALD (GB)
O'DONNELL MICHAEL (GB)
PIERARD FRANCOISE (GB)
PINDER JOANNE (GB)
STORCK PIERRE-HENRI (GB)
TWIN HEATHER (GB)
Application Number:
PCT/US2013/073477
Publication Date:
March 05, 2015
Filing Date:
December 06, 2013
Export Citation:
Assignee:
VERTEX PHARMA (US)
International Classes:
C07D487/04; A61K31/437; A61P35/00
Attorney, Agent or Firm:
STEWART, Rory, C. (86-88 Jubilee Avenue Milton Par, Abingdon Oxfordshire OX14 4RW, GB)
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