Title:
COMPOUNDS USEFUL FOR INHIBITION OF FARNESYL PROTEIN TRANSFERASE
Document Type and Number:
WIPO Patent Application WO1998011091
Kind Code:
A3
Abstract:
Novel compounds of formula (1.0) are disclosed. Compounds of formula (1.0) are represented by the compounds of formulas (1.4) or (1.5) wherein R<1>, R<3> and R<4> are each independently selected from halo. Also disclosed are methods of inhibiting farnesyl protein transferase and the growth of abnormal cells, such as tumor cells. 00000
Inventors:
TAVERAS ARTHUR G
MALLAMS ALAN K
AFONSO ADRIANO
REMISZEWSKI STACY W
NJOROGE F GEORGE
DOLL RONALD J
LALWANI TARIK
ALVAREZ CARMEN
MALLAMS ALAN K
AFONSO ADRIANO
REMISZEWSKI STACY W
NJOROGE F GEORGE
DOLL RONALD J
LALWANI TARIK
ALVAREZ CARMEN
Application Number:
PCT/US1997/019976
Publication Date:
June 11, 1998
Filing Date:
September 11, 1997
Export Citation:
Assignee:
SCHERING CORP (US)
International Classes:
A61K31/4545; C07D401/04; A61K31/496; A61K31/513; A61K31/5377; A61P35/00; C07D401/12; C07D401/14; C07D405/14; C07D409/14; C07D413/14; C07D417/14; C07D471/04; C07D521/00; (IPC1-7): C07D401/00
Domestic Patent References:
| WO1995010516A1 | 1995-04-20 | |||
| WO1995010515A1 | 1995-04-20 | |||
| WO1995010514A1 | 1995-04-20 | |||
| WO1996030363A1 | 1996-10-03 | |||
| WO1996030362A1 | 1996-10-03 | |||
| WO1996031478A1 | 1996-10-10 | |||
| WO1997023478A1 | 1997-07-03 |
Foreign References:
| EP0495484A1 | 1992-07-22 | |||
| EP0396083A1 | 1990-11-07 | |||
| EP0270818A1 | 1988-06-15 |
Other References:
BISHOP,W.R. ET AL.: "Novel Tricyclic Inhibitors of Farnesyl Protein Tranferase", J.BIOL.CHEM., vol. 270, no. 51, 22 December 1995 (1995-12-22), ROCKVILLE PIKE, pages 30611 - 30618, XP002050604
BUSS,J.E. ET AL.: "Farnesyl transferase inhibitors : the successes and surprises of a new class of potential cancer chemotherapeutics", CHEM.BIOL., vol. 2, December 1995 (1995-12-01), pages 787 - 791, XP002056549
NJOROGE,F.G. ET AL.: "Novel Tricyclic Aminoacetyl and Sulfonamide inhibitors of RAS farnesyl protein transferase", BIOORG.&MED.CHEM.LETT., vol. 6, no. 24, December 1996 (1996-12-01), OXFORD, pages 2977 - 2982, XP002056550
NJOROGE,F.G. ET AL.: "Discovery of a novel Nonpeptide Tricyclic Inhibitors of RAS Farnesyl Transferase", BIOORG.&MED.CHEM.LETT., vol. 5, no. 1, 1997, OXFORD, pages 101 - 113, XP002056551
BUSS,J.E. ET AL.: "Farnesyl transferase inhibitors : the successes and surprises of a new class of potential cancer chemotherapeutics", CHEM.BIOL., vol. 2, December 1995 (1995-12-01), pages 787 - 791, XP002056549
NJOROGE,F.G. ET AL.: "Novel Tricyclic Aminoacetyl and Sulfonamide inhibitors of RAS farnesyl protein transferase", BIOORG.&MED.CHEM.LETT., vol. 6, no. 24, December 1996 (1996-12-01), OXFORD, pages 2977 - 2982, XP002056550
NJOROGE,F.G. ET AL.: "Discovery of a novel Nonpeptide Tricyclic Inhibitors of RAS Farnesyl Transferase", BIOORG.&MED.CHEM.LETT., vol. 5, no. 1, 1997, OXFORD, pages 101 - 113, XP002056551
Download PDF:
Previous Patent: 3-alkyl-3-phenyl-piperidines
Next Patent: TRICYCLIC INHIBITORS OF FARNESYL PROTEIN TRANSFERASE
Next Patent: TRICYCLIC INHIBITORS OF FARNESYL PROTEIN TRANSFERASE