Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
COMPOUNDS AND USES THEREOF FOR DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE
Document Type and Number:
WIPO Patent Application WO2003051841
Kind Code:
A3
Abstract:
Carbamates and related compounds of formula R1 R2NCO-Y or R1 R2NCS-Y wherein R1 and R2 are hydrogen, alkyl, aryl, heteroaryl or may together form a piperidine, piperazine, morpholine or other heterocyclic ring, are inhibitors of hormone sensitive lipase and are useful for the treatment of any disorder where it is desirable to modulate the plasma level of free fatty acids, glycerol, LDL-cholesterol, HDL-cholesterol, insulin and/or glucose; and or modulate intracellular triacylglycerol and cholesterol stores, intracellular level of fatty acids, fatty acid esters such as diacylglycerols, phosphatidic acids, long chain acyl-CoA's as well as citrate or malonyl-CoA; and or increase insulin sensitivity ; and or modulate insulin secretion from pancreatic beta cells. More particularly said disorders are selected from the group consisting of insulin resistance, diabetes type 1, diabetes type 2, metabolic syndrome X, impaired glucose tolerance, hyperclycemia, dislipidemia, obesity, abnormalities of lipoprotein metabolism and any combinations. thereof.

Inventors:
EBDRUP SOEREN
CORNELIS DE JONG JOHANNES
JACOBSEN POUL
HANSEN HOLGER CLAUS
VEDSOE PER
Application Number:
DK0200852W
Publication Date:
June 24, 2004
Filing Date:
December 13, 2002
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
NOVO NORDISK A/S
International Classes:
C07D249/08; A61K31/16; A61K31/27; A61K31/275; A61K31/341; A61K31/343; A61K31/352; A61K31/37; A61K31/381; A61K31/40; A61K31/401; A61K31/4015; A61K31/4035; A61K31/4045; A61K31/407; A61K31/41; A61K31/415; A61K31/4155; A61K31/4164; A61K31/4184; A61K31/4192; A61K31/4196; A61K31/423; A61K31/426; A61K31/428; A61K31/437; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4439; A61K31/444; A61K31/445; A61K31/451; A61K31/4545; A61K31/455; A61K31/465; A61K31/47; A61K31/4709; A61K31/472; A61K31/4725; A61K31/473; A61K31/495; A61K31/496; A61K31/498; A61K31/4995; A61K31/50; A61K31/505; A61K31/5375; A61K31/5377; A61K31/541; A61K31/55; A61K31/551; A61K31/63; A61K45/00; A61P1/04; A61P1/18; A61P3/04; A61P3/06; A61P3/10; A61P5/50; A61P9/04; A61P9/06; A61P9/10; A61P9/12; A61P17/06; A61P21/04; A61P25/16; A61P25/22; A61P25/24; A61P25/28; A61P27/02; A61P29/00; A61P31/04; A61P31/18; A61P35/00; A61P43/00; C07C39/367; C07C233/25; C07C233/26; C07C233/60; C07C269/00; C07C271/58; C07C275/34; C07C303/34; C07C303/38; C07C307/06; C07C311/04; C07C311/17; C07C311/21; C07C311/29; C07C311/40; C07C317/22; C07C323/20; C07D207/325; C07D207/36; C07D207/40; C07D207/404; C07D209/08; C07D209/32; C07D209/48; C07D211/40; C07D211/88; C07D213/61; C07D213/63; C07D213/64; C07D213/643; C07D213/65; C07D213/68; C07D213/69; C07D213/70; C07D213/74; C07D213/75; C07D213/82; C07D213/84; C07D215/14; C07D215/20; C07D215/22; C07D217/06; C07D217/24; C07D221/14; C07D231/12; C07D231/14; C07D231/16; C07D231/18; C07D233/54; C07D233/60; C07D233/70; C07D233/84; C07D235/18; C07D235/26; C07D237/14; C07D239/22; C07D239/34; C07D239/38; C07D241/18; C07D241/44; C07D249/04; C07D249/12; C07D249/18; C07D253/04; C07D257/04; C07D261/12; C07D261/20; C07D263/52; C07D277/20; C07D277/24; C07D277/34; C07D277/68; C07D285/00; C07D285/01; C07D295/18; C07D295/20; C07D295/205; C07D295/26; C07D307/16; C07D307/28; C07D307/52; C07D307/89; C07D311/16; C07D311/18; C07D333/16; C07D333/32; C07D333/34; C07D333/40; C07D401/04; C07D401/12; C07D401/14; C07D403/12; C07D405/12; C07D405/14; C07D409/04; C07D409/12; C07D413/12; C07D417/12; C07D471/04; C07D471/06; C07D487/08; C07D487/18; C07D491/10; C07D513/04; C07D521/00; (IPC1-7): A61K31/325; A61K31/4196; A61K31/4192; A61K31/415; A61K31/352; A61K31/4035; A61K31/40; A61K31/404; A61K31/423; A61K31/42; A61K31/428; A61K31/44; A61K31/495; A61K31/505; A61K31/41
Domestic Patent References:
WO2000069810A12000-11-23
WO2002020483A12002-03-14
WO2002006189A22002-01-24
WO1999062870A11999-12-09
WO2002038153A12002-05-16
WO2001021584A12001-03-29
WO2000063208A12000-10-26
WO1998053814A11998-12-03
WO2000054759A22000-09-21
WO2001021602A12001-03-29
WO1992007838A11992-05-14
WO2001087843A12001-11-22
WO1995029155A11995-11-02
WO2002042257A12002-05-30
WO2002012210A12002-02-14
WO2003051842A22003-06-26
WO1992006075A11992-04-16
Foreign References:
EP1201649A12002-05-02
US5837727A1998-11-17
US5463062A1995-10-31
BE665273A1965-10-01
EP0587311A11994-03-16
GB1307923A1973-02-21
DE2336526A11975-02-06
US4016278A1977-04-05
GB982235A1965-02-03
US2449440A1948-09-14
DE2801187A11978-07-20
US4081461A1978-03-28
Other References:
DATABASE WPI Section Ch Week 199709, Derwent World Patents Index; Class B03, AN 1997-100136, XP002230558
WHEATLEY W.B. ET. AL.: "Benzylphenol Derivatives. VIII. Carbamates", J. AMER. CHEM. SOC., vol. 79, 1957, pages 747 - 749, XP002265513
SCHMIDT F ET AL: "Glucuronide prodrugs of hydroxy compounds for antibody directed enzyme prodrug therapy (adept): a phenol nitrogen mustard carbamate", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 7, no. 8, 22 April 1997 (1997-04-22), pages 1071 - 1076, XP004136187, ISSN: 0960-894X
NICULESCU-DUVAZ, ION ET AL: "New N-yperites of the urethane type from natural and synthetic hormones", REVISTADE CHIMIE (BUCHAREST, ROMANIA) (1967), 18(5), 296-9, XP008025905
NICULESCU-DUVAZ, ION ET AL: "Hypothesis concerning the mechanism of action of some new alkylating agents from synthetic estrogens", NEOPLASMA (1966), 13(6), 583-9, XP008025904
NICULESCU-DUVA, I. ET AL: "Potential anticancer agents. III. Urethan-type nitrogen mustards of some synthetic estrogens. I", CANADIAN JOURNAL OF CHEMISTRY (1966), 44(9), 1102-5, XP008025959
Download PDF: