Title:
COMPOUNDS WEAKENING SAICAR SYNTHASE ACTIVITY, AND APPLICATIONS
Document Type and Number:
WIPO Patent Application WO/2018/059396
Kind Code:
A1
Abstract:
Provided are compounds reducing SAICAR accumulation, and applications. On the basis of existing protein structure data and small molecule structure data, calculations and analysis are performed using software to screen and obtain compounds capable of effectively interfering with PAICS activity, reducing SAICAR synthesis, and ultimately reducing SAICAR accumulation, in order to achieve the goal of treating or improving ADSL deficiency. A better effect in the treatment or improvement of ADSL deficiency is expected from the joint use of at least two of the described compounds.
Inventors:
PAN WUGUANG (CN)
ZHU WEI (CN)
ZHU WEI (CN)
Application Number:
PCT/CN2017/103408
Publication Date:
April 05, 2018
Filing Date:
September 26, 2017
Export Citation:
Assignee:
GENEHEAL BIOTECHNOLOGY CO LTD (CN)
International Classes:
C07H21/00; A61K31/197; A61K31/198; A61K31/7076; A61K38/06; A61P3/00; A61P25/00
Domestic Patent References:
| WO2014067038A1 | 2014-05-08 |
Foreign References:
| US7056945B1 | 2006-06-06 | |||
| US6660719B2 | 2003-12-09 | |||
| US20140141010A1 | 2014-05-22 |
Other References:
CASEY, P. J. ET AL.: "Inhibition of Adenylosuccinate Lyase by L-alanosyl-5-aminoi-midazole-4-carboxylic Acid Ribonucleotide (alanosyl-AICOR", BIOCHEMICAL PHARMACOLOGY, vol. 36, no. 5, 31 December 1987 (1987-12-31), pages 705 - 709, XP002959671
CASEY, . J. ET AL.: "Metabolism of Threo-beta-Fluoroaspartate by H4 Cells", J. BIOL. CHEM., vol. 261, no. 29, 15 October 1986 (1986-10-15), pages 13637 - 13642, XP055500964
CASEY, . J. ET AL.: "Metabolism of Threo-beta-Fluoroaspartate by H4 Cells", J. BIOL. CHEM., vol. 261, no. 29, 15 October 1986 (1986-10-15), pages 13637 - 13642, XP055500964
Attorney, Agent or Firm:
JIAQUAN IP LAW FIRM (CN)
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