Title:
COMPOUNDS WHICH MIMIC THE CHEMICAL AND BIOLOGICAL PROPERTIES OF DISCODERMOLIDE
Document Type and Number:
WIPO Patent Application WO2002046150
Kind Code:
A3
Abstract:
Compounds which mimic the chemical and/or biological activity of discodermolide are provided and intermediates useful in their preparation.
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Inventors:
SMITH AMOS B III (US)
BEAUCHAMP THOMAS J (US)
LAMARCHE MATTHEW J
BEAUCHAMP THOMAS J (US)
LAMARCHE MATTHEW J
Application Number:
PCT/US2001/047958
Publication Date:
January 05, 2006
Filing Date:
December 06, 2001
Export Citation:
Assignee:
UNIV PENNSYLVANIA (US)
SMITH AMOS B III (US)
BEAUCHAMP THOMAS J (US)
LAMARCHE MATTHEW J
SMITH AMOS B III (US)
BEAUCHAMP THOMAS J (US)
LAMARCHE MATTHEW J
International Classes:
C07C239/06; C07C271/12; C07D213/30; C07D263/22; C07D303/16; C07D309/10; C07D309/30; C07D309/32; C07D319/06; C07D339/08; C07D407/06; C07D413/06; C07D413/12; C07D417/06; C07F7/18; (IPC1-7): C07D309/30
Other References:
SCOTT ET AL.: "Total synthesis of (-)-discodermolide: An application of chelation-controlled alkylation reaction", J. ORG. CHEM., vol. 62, no. 18, 1997, pages 6098 - 6099, XP002912690
HUNG ET AL.: "Synthesis of discodermolides useful for investigating microtubule binding and stabilization", J. AM. CHEM. SOC., vol. 118, no. 45, 1996, pages 11054 - 11080, XP000652059
HUNG ET AL.: "Synthesis of discodermolides useful for investigating microtubule binding and stabilization", J. AM. CHEM. SOC., vol. 118, no. 45, 1996, pages 11054 - 11080, XP000652059
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