Title:
COMPOUNDS WHICH SELECTIVELY MODULATE THE CB2 RECEPTOR
Document Type and Number:
WIPO Patent Application WO/2010/147792
Kind Code:
A3
Abstract:
Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
Inventors:
BARTOLOZZI ALESSANDRA (US)
HICKEY EUGENE RICHARD (US)
RIETHER DORIS (US)
WU LIFEN (US)
ZINDELL RENEE (US)
BLUMIRE NIGEL (GB)
ERMANN MONIKA (GB)
GLENN EDWARD THOMAS (GB)
KHOR SOMEINA (GB)
ZAWADZKI PRZEMYSLAW (PL)
HICKEY EUGENE RICHARD (US)
RIETHER DORIS (US)
WU LIFEN (US)
ZINDELL RENEE (US)
BLUMIRE NIGEL (GB)
ERMANN MONIKA (GB)
GLENN EDWARD THOMAS (GB)
KHOR SOMEINA (GB)
ZAWADZKI PRZEMYSLAW (PL)
Application Number:
PCT/US2010/037697
Publication Date:
September 01, 2011
Filing Date:
June 08, 2010
Export Citation:
Assignee:
BOEHRINGER INGELHEIM INT (DE)
BARTOLOZZI ALESSANDRA (US)
HICKEY EUGENE RICHARD (US)
RIETHER DORIS (US)
WU LIFEN (US)
ZINDELL RENEE (US)
BLUMIRE NIGEL (GB)
ERMANN MONIKA (GB)
GLENN EDWARD THOMAS (GB)
KHOR SOMEINA (GB)
ZAWADZKI PRZEMYSLAW (PL)
BARTOLOZZI ALESSANDRA (US)
HICKEY EUGENE RICHARD (US)
RIETHER DORIS (US)
WU LIFEN (US)
ZINDELL RENEE (US)
BLUMIRE NIGEL (GB)
ERMANN MONIKA (GB)
GLENN EDWARD THOMAS (GB)
KHOR SOMEINA (GB)
ZAWADZKI PRZEMYSLAW (PL)
International Classes:
C07D261/14; A61K31/42; A61P29/00; C07D413/12; C07D413/14; C07D417/06; C07D417/12; C07D417/14
Other References:
DIMITRA HADJIPAVLOU-LITINA ET AL.: "Thiazolyl-N-substituted amides: a group of effective anti-inflammatory agents with potential for local anesthetic properties. Synthesis, biological evaluation and a QSAR approach", DRUG DEVELOPMENT RESEARCH, vol. 48, 1999, pages 53 - 60, XP002599014
DATABASE BEILSTEIN [online] BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; 1966, XP002599015, Database accession no. 1084348
DATABASE BEILSTEIN [online] BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; 1974, XP002599016, Database accession no. 1179643
DATABASE BEILSTEIN [online] BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; 1974, XP002599017, Database accession no. 5396840
DATABASE BEILSTEIN [online] BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; 1978, XP002599018, Database accession no. 5398283
DATABASE BEILSTEIN [online] BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; 1972, XP002599019, Database accession no. 857451
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1996, XP002599020, retrieved from STN Database accession no. 126:89390
DATABASE BEILSTEIN [online] BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; 1966, XP002599015, Database accession no. 1084348
DATABASE BEILSTEIN [online] BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; 1974, XP002599016, Database accession no. 1179643
DATABASE BEILSTEIN [online] BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; 1974, XP002599017, Database accession no. 5396840
DATABASE BEILSTEIN [online] BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; 1978, XP002599018, Database accession no. 5398283
DATABASE BEILSTEIN [online] BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; 1972, XP002599019, Database accession no. 857451
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1996, XP002599020, retrieved from STN Database accession no. 126:89390
Attorney, Agent or Firm:
MORRIS, Michael, P. et al. (Inc.900 Ridgebury Road,P.O. Box 36, Ridgefield CT, US)
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