Title:
COMPOUNDS WITH ACTIVITY AT ESTROGEN RECEPTOR
Document Type and Number:
WIPO Patent Application WO2005108337
Kind Code:
A3
Abstract:
Disclosed herein are novel di-phenyl compounds and methods for using various di-phenyl compounds for treatment and prevention of diseases and disorders related to estrogen receptors.
Inventors:
OLSSON ROGER (SE)
HYLDTOFT LENE (DK)
PIU FABRICE (US)
GUSTAFSSON MAGNUS (DK)
HYLDTOFT LENE (DK)
PIU FABRICE (US)
GUSTAFSSON MAGNUS (DK)
Application Number:
PCT/US2005/015221
Publication Date:
December 22, 2005
Filing Date:
May 03, 2005
Export Citation:
Assignee:
ACADIA PHARM INC (US)
OLSSON ROGER (SE)
HYLDTOFT LENE (DK)
PIU FABRICE (US)
GUSTAFSSON MAGNUS (DK)
OLSSON ROGER (SE)
HYLDTOFT LENE (DK)
PIU FABRICE (US)
GUSTAFSSON MAGNUS (DK)
International Classes:
A61K31/05; A61K31/055; A61P5/30; C07C17/26; C07C37/14; C07C39/00; C07C39/12; C07C39/17; C07C39/42; C07C43/21; C07C43/225; C07C43/23; C07C43/30; C07C49/753; C07C59/72; C07C65/26; C07D309/12; (IPC1-7): C07C39/42; C07C39/17; C07C43/21; A61K31/05; A61K31/055; A61P5/30
Domestic Patent References:
| WO2000010958A1 | 2000-03-02 | |||
| WO2001010385A2 | 2001-02-15 | |||
| WO2002018334A2 | 2002-03-07 |
Foreign References:
| US4247484A | 1981-01-27 | |||
| US4554309A | 1985-11-19 | |||
| US4082913A | 1978-04-04 | |||
| US3517071A | 1970-06-23 | |||
| US5283374A | 1994-02-01 | |||
| EP0995737A1 | 2000-04-26 | |||
| US6255439B1 | 2001-07-03 | |||
| GB1410275A | 1975-10-15 | |||
| US2342294A | 1944-02-22 |
Other References:
MUTHYALA R.S. ET AL: "Exploration of the Bicyclo[3.3.1]nonane System as a Template for New Ligands for the Estrogen Receptor", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 13, 2003, pages 4485 - 4488, XP002351134
YAMASAKI K. ET AL: "Comparative study of the uterotrophic potency of 14 chemicals in a uterotrophic assay and their receptor-binding affinity", TOXICOLOGY LETTERS, vol. 146, 2004, pages 111 - 120, XP002351135
GALLEGOS SALINER A. ET AL.: "Molecular Quantum Similarity Analysis of Estrogenic Activity", J. CHEM . INF. COMPUT. SCI., vol. 43, 2003, pages 1166-1176, XP002351136
MUTHYALA R.S. ET AL.: "Bridged Bicyclic Cores Containing a 1,1-Diarylethylene Motif are High- Affinity Subtype-Selective Ligands for the Estrogen Receptor", J. MED. CHEM., vol. 46, 2003, pages 1589 - 1602, XP002351137
YAMASAKI K. ET AL.: "Comparison of the reporter gene assay for ER-alpha antagonists with the immmature rat uterotrophic assay of 10 chemicals", TOXYCOLOGY LETTERS, vol. 142, 2003, pages 119 - 131, XP002351138
COLEMAN K.P. ET AL: "QSAR Models of the in vitro Strogen Activity ofBisphenol A Analogs", QSAR COMB. SCI., vol. 22, 2003, pages 78 - 88, XP009056011
NIEDERL B.: "Steric Hindrance in Ketone-Phenol Condensations. The Condensation of Guaiacol with Cyclic Ketones", J. AM. CHEM. SOC., vol. 62, 1940, pages 320 - 322, XP002351139
DATABASE BEILSTEIN Institut für Förderung der Chemischen Wissenschaften; XP002351600, accession no. 3156998, 3519057, 3156998, 3519057
DATABASE BEILSTEIN Institut für Förderung der Chemischen Wissenschaften; XP002351601, Database accession no. 8372608, 9453634, 9455728, 8372608, 9455728
YAMASAKI K. ET AL: "Comparative study of the uterotrophic potency of 14 chemicals in a uterotrophic assay and their receptor-binding affinity", TOXICOLOGY LETTERS, vol. 146, 2004, pages 111 - 120, XP002351135
GALLEGOS SALINER A. ET AL.: "Molecular Quantum Similarity Analysis of Estrogenic Activity", J. CHEM . INF. COMPUT. SCI., vol. 43, 2003, pages 1166-1176, XP002351136
MUTHYALA R.S. ET AL.: "Bridged Bicyclic Cores Containing a 1,1-Diarylethylene Motif are High- Affinity Subtype-Selective Ligands for the Estrogen Receptor", J. MED. CHEM., vol. 46, 2003, pages 1589 - 1602, XP002351137
YAMASAKI K. ET AL.: "Comparison of the reporter gene assay for ER-alpha antagonists with the immmature rat uterotrophic assay of 10 chemicals", TOXYCOLOGY LETTERS, vol. 142, 2003, pages 119 - 131, XP002351138
COLEMAN K.P. ET AL: "QSAR Models of the in vitro Strogen Activity ofBisphenol A Analogs", QSAR COMB. SCI., vol. 22, 2003, pages 78 - 88, XP009056011
NIEDERL B.: "Steric Hindrance in Ketone-Phenol Condensations. The Condensation of Guaiacol with Cyclic Ketones", J. AM. CHEM. SOC., vol. 62, 1940, pages 320 - 322, XP002351139
DATABASE BEILSTEIN Institut für Förderung der Chemischen Wissenschaften; XP002351600, accession no. 3156998, 3519057, 3156998, 3519057
DATABASE BEILSTEIN Institut für Förderung der Chemischen Wissenschaften; XP002351601, Database accession no. 8372608, 9453634, 9455728, 8372608, 9455728
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