Title:
COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2019/145726
Kind Code:
A9
Abstract:
Compounds of general formula (I): wherein R1, R2, R3, R4, R5a, R5b X1, X2, Z and Y are as defined herein are positive modulators of the calcium-activated chloride channel (CaCC), TMEM16A. The compounds are useful for treating diseases and conditions affected by modulation of TMEM16A, particularly respiratory diseases and conditions.
Inventors:
COLLINGWOOD STEPHEN (GB)
MCCARTHY CLIVE (GB)
HARGRAVE JONATHAN (GB)
HAY DUNCAN (GB)
SCHOFIELD THOMAS (GB)
ELLAM SARAH (GB)
BUXTON CRAIG (GB)
HABGOOD MATTHEW (GB)
INGRAM PETER (GB)
MA CHUN YAN (GB)
NAPIER SPENCER (GB)
SHAIKH ABDUL (GB)
SMITH MATTHEW (GB)
STIMSON CHRISTOPHER (GB)
WALKER EDWARD (GB)
MCCARTHY CLIVE (GB)
HARGRAVE JONATHAN (GB)
HAY DUNCAN (GB)
SCHOFIELD THOMAS (GB)
ELLAM SARAH (GB)
BUXTON CRAIG (GB)
HABGOOD MATTHEW (GB)
INGRAM PETER (GB)
MA CHUN YAN (GB)
NAPIER SPENCER (GB)
SHAIKH ABDUL (GB)
SMITH MATTHEW (GB)
STIMSON CHRISTOPHER (GB)
WALKER EDWARD (GB)
Application Number:
PCT/GB2019/050209
Publication Date:
September 12, 2019
Filing Date:
January 25, 2019
Export Citation:
Assignee:
ENTERPRISE THERAPEUTICS LTD (GB)
International Classes:
C07D213/72; A61P11/00; C07C1/00; C07D309/10; C07D401/12; C07D405/12; C07D413/12; C07D417/12
Attorney, Agent or Firm:
TEUTEN, Andrew et al. (GB)
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