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Title:
COMPREHENSIVE AND QUANTITATIVE LIPID AND TOCOPHEROL ANALYSIS
Document Type and Number:
WIPO Patent Application WO/2018/183448
Kind Code:
A8
Abstract:
A method for determining in a sample, by mass spectrometry, the presence, absence or amount of one or more lipid species from one or more lipid classes is described herein. The one or more lipid classes are selected from the group consisting of wax esters (WE), squalene (SQ), triacylglycerols (TAG), diacylglycerols (DAG), free fatty acids (FFA), cholesteryl esters (CE), cholesterol (CH), and combinations thereof. The method includes a) subjecting the sample to an ionization source under conditions suitable to produce one or more ions detectable by mass spectrometry from each of the one or more of the lipid species; b) measuring, by mass spectrometry, the amount of the one or more ions from each of the one or more lipid species; and c) using the measured amount of the one or more ions to determine the presence, absence or amount of each of the one or more lipid species in the sample.

Inventors:
FREINKMAN, Elizaveta (102 Marble Falls Way, Cary, NC, 27519, US)
EVANS, Anne, M. (2801 Cameron Pond Drive, Cary, NC, 27519, US)
GOODMAN, Kelli (3812 April Place, Raleigh, NC, 27612, US)
ROBINSON, Richard, J. (2024 Kirkhaven Drive, Morrisville, NC, 27560, US)
Application Number:
US2018/024767
Publication Date:
October 17, 2019
Filing Date:
March 28, 2018
Export Citation:
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Assignee:
METABOLON, INC. (617 Davis Drive, Suite 400Morrisville, NC, 27560, US)
International Classes:
H01J49/26; G01N33/82; G01N33/92
Attorney, Agent or Firm:
ELLIOTT, Allyn B. et al. (NK Patent Law, PLLC4917 Waters Edge Drive, Suite 27, Raleigh NC, 27606, US)
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