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Title:
A COMPUTER BASED METHOD FOR IDENTIFYING CONSERVED INVARIANT PEPTIDE MOTIFS
Document Type and Number:
WIPO Patent Application WO2001074130
Kind Code:
A3
Abstract:
The present invention relates to a novel computer based method for performing genomewise comparison of several organisms, the said computational method involves creation of peptide libraries from protein sequences of several organisms and subsequent comparison leading to identification of conserved invariant peptide motifs, and to this end several invariant peptide motifs have been identified by direct sequence comparison between various bacterial organisms and host genomes without any a priori assumptions, and the present method is useful for identification of potential drug targets and can serve as drug screen for broad-spectrum antibacterial as well as for specific diagnosis of infections, and in addition, for assignment of function to proteins of yet unknown functions with the help of such invariant peptide motif signatures.

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Inventors:
BRAHMACHARI KUMAR SAMIR (IN)
DASH DEBASIS (IN)
Application Number:
PCT/IN2000/000085
Publication Date:
January 24, 2002
Filing Date:
August 31, 2000
Export Citation:
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Assignee:
COUNCIL SCIENT IND RES (IN)
BRAHMACHARI KUMAR SAMIR (IN)
DASH DEBASIS (IN)
International Classes:
C07K1/00; C07K14/195; C12N15/09; G01N33/483; C12Q1/00; G16B35/10; C12Q1/68; C40B50/02; G01N33/68; G16B20/00; G16B30/10; (IPC1-7): C07K1/00; C07K14/195; G06F17/50
Domestic Patent References:
WO1999050770A11999-10-07
Other References:
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; FETROW, JACQUELYN S. ET AL: "Method for prediction of protein function from sequence using the sequence-to-structure-to-function paradigm with application to glutaredoxins/thioredoxins and T1 ribonucleases", XP002177644, retrieved from STN Database accession no. 129:299433 CA
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; MULLER, ARNE ET AL: "Benchmarking PSI-BLAST in Genome Annotation", XP002177645, retrieved from STN Database accession no. 132:118313 CA
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