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Title:
CONCENTRATED PARENTERAL METHOTRAXATE FORMULATIONS
Document Type and Number:
WIPO Patent Application WO/2016/093781
Kind Code:
A1
Abstract:
The present invention relates to a parenteral administration of methotraxate for the treatment of inflammatory autoimmune diseases, wherein methotraxate is formulated at a concentration of 40mg/mL in a pharmaceutically acceptable solvent.

Inventors:
KOÇAK ENDER (TR)
Application Number:
TR2015/050136
Publication Date:
June 16, 2016
Filing Date:
October 12, 2015
Export Citation:
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Assignee:
KOÇAK FARMA İLAÇ VE KİMYA SANAYİ ANONİM ŞİRKETİ (TR)
International Classes:
A61K31/519; A61P29/00
Domestic Patent References:
WO2013019908A12013-02-07
Foreign References:
EP2012070074W2012-10-10
US8644231B22014-02-04
Other References:
ANONYMOUS: "OTREXUP - methotrexate injection, solution", November 2014 (2014-11-01), XP002754403, Retrieved from the Internet [retrieved on 20160215]
MÜLLER-LADNER ULF ET AL: "Tolerability and patient/physician satisfaction with subcutaneously administered methotrexate provided in two formulations of different drug concentrations in patients with rheumatoid arthritis.", THE OPEN RHEUMATOLOGY JOURNAL 2010, vol. 4, 2010, pages 15 - 22, XP002754404, ISSN: 1874-3129
ANONYMOUS: "Metoject PEN", August 2013 (2013-08-01), XP002754405, Retrieved from the Internet [retrieved on 20160215]
ANONYMOUS: "METHOTREXATE - methotrexate sodium injection, solution", 31 July 2012 (2012-07-31), XP002754406, Retrieved from the Internet [retrieved on 20160215]
PHARMACOL REV, vol. 57, 2005, pages 163 - 172
MAKWANA ET AL., INT. J. INVESTIG., vol. 1, 2011, pages 200
Attorney, Agent or Firm:
4M DANIŞMANLIK TIC. LTD. ŞTI. (Maltepe, Çankaya/Ankara, TR)
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