Title:
CONDENSED CAMPTOTHECINS AS ANTITUMOR AGENTS
Document Type and Number:
WIPO Patent Application WO2003045952
Kind Code:
A3
Abstract:
The present invention relates to hexacyclic compound of the formula [1], wherein Z, R<1>, R<2>, R<3> and R<4> are as defined in the description and claims and pharmaceutically acceptable salts thereof. These compounds are useful in the treatment of cell proliferative disorders.
Inventors:
MURATA TAKESHI
NIIZUMA SATOSHI
SHIMMA NOBUO
SUDA HITOMI
TSUKAZAKI MASAO
NIIZUMA SATOSHI
SHIMMA NOBUO
SUDA HITOMI
TSUKAZAKI MASAO
Application Number:
PCT/EP2002/013216
Publication Date:
October 16, 2003
Filing Date:
November 25, 2002
Export Citation:
Assignee:
HOFFMANN LA ROCHE (CH)
International Classes:
A61K31/519; A61K31/5377; A61P35/00; A61P43/00; C07D491/22; (IPC1-7): C07D491/22
Domestic Patent References:
| WO1999005103A2 | 1999-02-04 | |||
| WO1996038146A1 | 1996-12-05 | |||
| WO1995022549A1 | 1995-08-24 |
Foreign References:
| EP0296597A2 | 1988-12-28 | |||
| EP0495432A1 | 1992-07-22 | |||
| EP0471358A1 | 1992-02-19 |
Other References:
A. BEDESCHI ET AL.: "Syntheis and antitumor activity of a new class of water soluble camptothecin derivatives", BIOORG. MED. CHEM. LETT., vol. 6, no. 6, 1996, pages 671 - 674, XP002239568
M. SUGIMORI ET AL.: "Synthesis and Antitumor Activity of Ring A- and F-Modified Hexacyclic Camptothecin Analogues", J. MED. CHEM., vol. 41, no. 13, 1998, pages 2308 - 2318, XP002239569
PATENT ABSTRACTS OF JAPAN vol. 018, no. 347 30 June 1994 (1994-06-30)
M. SUGIMORI ET AL.: "Antitumor Agents. 7. Synthesis and Antitumor Activity of Novel Hexacyclic Camptothecin Analogues", J. MED. CHEM., vol. 37, no. 19, 1994, pages 3033 - 3039, XP002239570
M. SUGIMORI ET AL.: "Synthesis and Antitumor Activity of Ring A- and F-Modified Hexacyclic Camptothecin Analogues", J. MED. CHEM., vol. 41, no. 13, 1998, pages 2308 - 2318, XP002239569
PATENT ABSTRACTS OF JAPAN vol. 018, no. 347 30 June 1994 (1994-06-30)
M. SUGIMORI ET AL.: "Antitumor Agents. 7. Synthesis and Antitumor Activity of Novel Hexacyclic Camptothecin Analogues", J. MED. CHEM., vol. 37, no. 19, 1994, pages 3033 - 3039, XP002239570
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