Title:
CONDENSED PYRIMIDINE DERIVATIVE AND XANTHINE OXIDASE INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2005/121153
Kind Code:
A1
Abstract:
Disclosed is a compound represented by the following general formula (I) (wherein R1 represents an aryl group having 6-10 carbon atoms or a heteroaryl group which may have, as a substituent, a group selected from an alkyl group having 1-8 carbon atoms, an alkyl group having 1-8 carbon atoms which is substituted with a halogen atom, an alkoxy group having 1-8 carbon atoms, an alkoxy group having 1-8 carbon atoms which is substituted with an alkoxy group having 1-8 carbon atoms, an alkoxycarbonyl group having 2-8 carbon atoms, a formyl group, a carboxyl group, a halogen atom, a hydroxyl group, a nitro group, a cyano group, an amino group, an aryl group having 6-10 carbon atoms and an aryloxy group having 6-10 carbon atoms; R2 represents a cyano group, a nitro group or the like; R3 represents an hydroxyl group or the like; X represents an oxygen atom, a sulfur atom or the like; and Y represents an oxygen atom or a sulfur atom). Also disclosed is a xanthine oxidase inhibitor containing such a compound.
Inventors:
YOSHIDA SHINICHI (JP)
KOBAYASHI KUNIO (JP)
MOCHIDUKI NOBUTAKA (JP)
YAMAKAWA TOMIO (JP)
KOBAYASHI TADASHI (JP)
SHINOHARA YORIKO (JP)
KOBAYASHI KUNIO (JP)
MOCHIDUKI NOBUTAKA (JP)
YAMAKAWA TOMIO (JP)
KOBAYASHI TADASHI (JP)
SHINOHARA YORIKO (JP)
Application Number:
PCT/JP2005/011188
Publication Date:
December 22, 2005
Filing Date:
June 13, 2005
Export Citation:
Assignee:
NIPPON CHEMIPHAR CO (JP)
YOSHIDA SHINICHI (JP)
KOBAYASHI KUNIO (JP)
MOCHIDUKI NOBUTAKA (JP)
YAMAKAWA TOMIO (JP)
KOBAYASHI TADASHI (JP)
SHINOHARA YORIKO (JP)
YOSHIDA SHINICHI (JP)
KOBAYASHI KUNIO (JP)
MOCHIDUKI NOBUTAKA (JP)
YAMAKAWA TOMIO (JP)
KOBAYASHI TADASHI (JP)
SHINOHARA YORIKO (JP)
International Classes:
A61K31/519; A61P19/06; A61P43/00; C07D498/04; C07D513/04; (IPC1-7): C07D498/04; A61K31/519; A61P19/06; A61P43/00; C07D513/04
Domestic Patent References:
| WO2003042185A1 | 2003-05-22 | |||
| WO1992009279A1 | 1992-06-11 | |||
| WO1998018765A1 | 1998-05-07 | |||
| WO1998018765A1 | 1998-05-07 | |||
| WO2003042185A1 | 2003-05-22 |
Foreign References:
| JPH03163082A | 1991-07-15 | |||
| JP2000001431A | 2000-01-07 | |||
| JPS6421431A | 1989-01-24 | |||
| EP1452528A1 | 2004-09-01 |
Other References:
BAKER B. ET AL.: "Inrreversible Enzyme Inhibitors. CXXV. Active-Site_directed Irreversible Inhibitors of Xanthine Oxidase Derived from Arylpurines and Pyrazolo (3,4-d)pyramidines Bearing a Terminal Sulfonyl Fluoride.", J. MED. CHEM., vol. 11, 1968, pages 656 - 661, XP002963445
BAKER B. ET AL.: "Irreversible Enzyme Inhibitors. CXXVI. Hydrocarbon Interaction with Xanthine Oxidaese by Phenyl Substituents on Purines and Pyrazolo(3,4-d)pyramidines.", J. MED.CHEM., vol. 11, 1968, pages 661 - 666, XP002963444
O´NEIL M. ET AL.: "Allopurinol.", THE MERCK INDEX., no. 276, 2001, pages 52 - 53, XP002990904
BAKER B. ET AL.: "Irreversible Enzyme Inhibitors. CXXVI. Hydrocarbon Interaction with Xanthine Oxidaese by Phenyl Substituents on Purines and Pyrazolo(3,4-d)pyramidines.", J. MED.CHEM., vol. 11, 1968, pages 661 - 666, XP002963444
O´NEIL M. ET AL.: "Allopurinol.", THE MERCK INDEX., no. 276, 2001, pages 52 - 53, XP002990904
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