Title:
CONDITIONALLY IMMORTALIZED CELLS AND METHODS FOR THEIR PREPARATION
Document Type and Number:
WIPO Patent Application WO/2018/135948
Kind Code:
A8
Abstract:
The invention relates to genetically modified conditionally immortalized cells and cell lines, provided with a vector comprising a promoter sequence, at least one immortalization gene operably linked to said promoter sequence, a gene coding for an inducible regulator operably linked to said promoter sequence and a response element for said inducible regulator. The invention further relates to methods for their preparation, and to immortalization and differentiation of such cells.
Inventors:
DE VRIES ANTONIUS ADRIANUS FRANCISCUS (NL)
PIJNAPPELS DANIËL ANTONIE (NL)
SCHALY MARTIN JAN (NL)
PIJNAPPELS DANIËL ANTONIE (NL)
SCHALY MARTIN JAN (NL)
Application Number:
PCT/NL2018/050046
Publication Date:
September 06, 2019
Filing Date:
January 23, 2018
Export Citation:
Assignee:
ACADEMISCH ZIEKENHUIS LEIDEN (NL)
International Classes:
C12N5/077
Attorney, Agent or Firm:
JANSEN, C.M. (NL)
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