Title:
CONDUCTIVE HYDROGEL PAPER-BASED DEVICE FOR SYNCHRONOUSLY MONITORING PHYSIOLOGICAL AND BIOCHEMICAL PARAMETERS
Document Type and Number:
WIPO Patent Application WO/2023/015969
Kind Code:
A1
Abstract:
A conductive hydrogel paper-based device for synchronously monitoring physiological and biochemical parameters. Self-assembly is implemented on a paper fiber by means of porous PEDOT:PSS hydrogel, such that the paper fiber has good conductivity and good water wettability, thereby achieving efficient electron transport and substance diffusion, and ensuring that the paper fiber can be used as a low-impedance electrocardio sensor and a high-sensitivity electrochemical sensor. Meanwhile, a spontaneous capillary flow effect allows a filter paper to act as a hydrophilic channel of a paper microfluid for capturing and analyzing sweat. During a motion test, a hydrogel paper patch is attached to the surface of skin to acquire electrocardio data and the concentration of a target substance in the sweat, thereby implementing non-invasive monitoring. A flexible, low-cost and multifunctional paper analysis apparatus can be implemented for synchronously monitoring physiological and biochemical signals in a movement process.
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Inventors:
LIANG BO (CN)
LI TIANYU (CN)
YE ZHICHAO (CN)
YE XUESONG (CN)
LI TIANYU (CN)
YE ZHICHAO (CN)
YE XUESONG (CN)
Application Number:
PCT/CN2022/090856
Publication Date:
February 16, 2023
Filing Date:
May 05, 2022
Export Citation:
Assignee:
UNIV ZHEJIANG (CN)
International Classes:
A61B5/0205; A61B5/268; A61B5/28; G01N27/327
Domestic Patent References:
| WO2013039151A1 | 2013-03-21 | |||
| WO2017122178A1 | 2017-07-20 |
Foreign References:
| CN113647941A | 2021-11-16 | |||
| CN109060923A | 2018-12-21 | |||
| CN110658248A | 2020-01-07 | |||
| CN103558268A | 2014-02-05 | |||
| CN112932494A | 2021-06-11 | |||
| US20200333829A1 | 2020-10-22 |
Other References:
LIANG BO; CAO QINGPENG; MAO XIYU; PAN WENHAO; TU TINGTING; FANG LU; YE XUESONG: "An Integrated Paper-Based Microfluidic Device for Real-Time Sweat Potassium Monitoring", IEEE SENSORS JOURNAL, IEEE, USA, vol. 21, no. 8, 15 July 2020 (2020-07-15), USA, pages 9642 - 9648, XP011843976, ISSN: 1530-437X, DOI: 10.1109/JSEN.2020.3009327
CAO QINGPENG, LIANG BO, TU TINGTING, WEI JINWEI, FANG LU, YE XUESONG: "Three-dimensional paper-based microfluidic electrochemical integrated devices (3D-PMED) for wearable electrochemical glucose detection", RSC ADVANCES, vol. 9, no. 10, 14 February 2019 (2019-02-14), pages 5674 - 5681, XP093034347, DOI: 10.1039/C8RA09157A
CAO QINGPENG, BO LIANG, XIYU MAO, JINWEI WEI, TINGTING TU, LU FANG, XUESONG YE: "A Smartwatch Integrated with a Paper-based Microfluidic Patch for Sweat Electrolytes Monitoring", ELECTROANALYSIS, vol. 33, no. 3, 30 July 2020 (2020-07-30), pages 643 - 651, XP093034351, DOI: 10.1002/elan.202060025
CAO QINGPENG, LIANG BO, TU TINGTING, WEI JINWEI, FANG LU, YE XUESONG: "Three-dimensional paper-based microfluidic electrochemical integrated devices (3D-PMED) for wearable electrochemical glucose detection", RSC ADVANCES, vol. 9, no. 10, 14 February 2019 (2019-02-14), pages 5674 - 5681, XP093034347, DOI: 10.1039/C8RA09157A
CAO QINGPENG, BO LIANG, XIYU MAO, JINWEI WEI, TINGTING TU, LU FANG, XUESONG YE: "A Smartwatch Integrated with a Paper-based Microfluidic Patch for Sweat Electrolytes Monitoring", ELECTROANALYSIS, vol. 33, no. 3, 30 July 2020 (2020-07-30), pages 643 - 651, XP093034351, DOI: 10.1002/elan.202060025
Attorney, Agent or Firm:
HANGZHOU QIUSHI PATENT OFFICE CO., LTD. (CN)
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