CONFORMATIONALLY RESTRICTED DINUCLEOTIDE MONOMERS AND OLIGONUCLEOTIDES

Title:

CONFORMATIONALLY RESTRICTED DINUCLEOTIDE MONOMERS AND OLIGONUCLEOTIDES

Document Type and Number:

WIPO Patent Application WO/2011/133868

Kind Code:

A3

Abstract:

This invention relates to conformationally locked dinucleotide motifs for exo- and phosphate stabilization. For instance, oligonucleotides can be prepared having one or more of the following formulas (IV-IX).

Inventors:

MANOHARAN MUTHIAH (US)
LACKEY JEREMY (US)
RAJEEV KALLANTHOTTATHIL G (US)
ZLATEV IVAN (US)

Application Number:

PCT/US2011/033588

Publication Date:

January 12, 2012

Filing Date:

April 22, 2011

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Assignee:

ALNYLAM PHARMACEUTICALS INC (US)
MANOHARAN MUTHIAH (US)
LACKEY JEREMY (US)
RAJEEV KALLANTHOTTATHIL G (US)
ZLATEV IVAN (US)

International Classes:

C07H19/20; C07H19/10; C07H21/02; C07H21/04

Other References:

PAWAN K. SHARMA ET AL: "A cyclic dinucleotide with a four-carbon 5'-C-to-5'-C connection; synthesis by RCM, NMR-examination and incorporation into secondary nucleic acid structures", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 4, no. 12, 1 January 2006 (2006-01-01), pages 2433, XP055011487, ISSN: 1477-0520, DOI: 10.1039/b603830a

Attorney, Agent or Firm:

TOWNES, Jeffrey, N. (2318 Mill RoadSuite 110, Alexandria VA, US)

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