Title:
CONJUGATE OF BIOTIN VARIANT DIMER WITH PHTHALOCYANINE PIGMENT
Document Type and Number:
WIPO Patent Application WO/2020/032165
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a conjugate of a biotin variant dimer with a phthalocyanine pigment to be used in photoimmunotherapy. Provided is a conjugate of a compound represented by formula (1) or a salt thereof with a phthalocyanine pigment. (In the formula, each symbol is as defined in the description.)
Inventors:
KANAI MOTOMU (JP)
YAMATSUGU KENZO (JP)
TATSUMI TOSHIFUMI (JP)
TAKAHASHI KAZUKI (JP)
KODAMA TATSUHIKO (JP)
TANAKA TOSHIYA (JP)
YAMASHITA TAKEFUMI (JP)
SUGIYAMA AKIRA (JP)
TSUKAGOSHI MASANOBU (JP)
YAMATSUGU KENZO (JP)
TATSUMI TOSHIFUMI (JP)
TAKAHASHI KAZUKI (JP)
KODAMA TATSUHIKO (JP)
TANAKA TOSHIYA (JP)
YAMASHITA TAKEFUMI (JP)
SUGIYAMA AKIRA (JP)
TSUKAGOSHI MASANOBU (JP)
Application Number:
PCT/JP2019/031336
Publication Date:
February 13, 2020
Filing Date:
August 08, 2019
Export Citation:
Assignee:
UNIV TOKYO (JP)
SAVID THERAPEUTICS INC (JP)
SAVID THERAPEUTICS INC (JP)
International Classes:
A61K47/54; A61K31/695; A61K41/00; A61P35/00; C07K14/36; C07K16/22; C07K16/30; C07K16/32; C07K19/00; C09B47/18; C12N15/76
Domestic Patent References:
| WO2015125820A1 | 2015-08-27 | |||
| WO2017031367A1 | 2017-02-23 | |||
| WO2018151301A1 | 2018-08-23 | |||
| WO2015125820A1 | 2015-08-27 | |||
| WO2014129446A1 | 2014-08-28 | |||
| WO2018007239A1 | 2018-01-11 |
Foreign References:
| CN105418643A | 2016-03-23 | |||
| JPS6127045B2 | 1986-06-24 | |||
| JP2017524659A | 2017-08-31 | |||
| US7005518B2 | 2006-02-28 | |||
| US5608060A | 1997-03-04 | |||
| US7626011B2 | 2009-12-01 | |||
| JP2018149295A | 2018-09-27 |
Other References:
KAWATA ATSUSHI : "Optical imaging using near-infrared fluorescent dye IRDye and application examples ", JSMI REPORT, vol. 10, no. 1, 2016, pages 43 - 45, XP009525667, ISSN: 1882-6490
ALESSANDRO PRATESI; GINANNESCHI MAURO; MELANI FABRIZIO; CHINOL MARCO; CAROLLO ANGELA; PAGANELLI GIOVANNI; LUMINI MARCO; BARTOLI MA: "Design and solid phase synthesis of new DO conjugated (+)-biotin dimers planned to develop molecular weight-tuned avidin oligomers", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 13, no. 13, February 2015 (2015-02-01), pages 3988 - 4001, XP055685812, ISSN: 1477-0520, DOI: 10.1039/C4OB02685C
ZHANG H ET AL.: "Therapeutic potential of an anti-HER2 single chain antibody-DM1 conjugates for the treatment of HER2-positive cancer", SIGNAL TRANSDUCT TARGET THER, vol. 2, 19 May 2017 (2017-05-19), pages 17015
See also references of EP 3834845A4
ALESSANDRO PRATESI; GINANNESCHI MAURO; MELANI FABRIZIO; CHINOL MARCO; CAROLLO ANGELA; PAGANELLI GIOVANNI; LUMINI MARCO; BARTOLI MA: "Design and solid phase synthesis of new DO conjugated (+)-biotin dimers planned to develop molecular weight-tuned avidin oligomers", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 13, no. 13, February 2015 (2015-02-01), pages 3988 - 4001, XP055685812, ISSN: 1477-0520, DOI: 10.1039/C4OB02685C
ZHANG H ET AL.: "Therapeutic potential of an anti-HER2 single chain antibody-DM1 conjugates for the treatment of HER2-positive cancer", SIGNAL TRANSDUCT TARGET THER, vol. 2, 19 May 2017 (2017-05-19), pages 17015
See also references of EP 3834845A4
Attorney, Agent or Firm:
SIKS & CO. (JP)
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