Title:
CONJUGATE OF NUCLEOTIDE ANALOG-CONTAINING DOUBLE-STRANDED RNAI ANALOG
Document Type and Number:
WIPO Patent Application WO/2023/208128
Kind Code:
A1
Abstract:
Disclosed is a conjugate of a nucleotide analog-containing double-stranded RNAi analog, and specifically disclosed are a sequence composition and a ligand structure of a conjugate of the double-stranded RNAi analog.
Inventors:
LU JIANYU (CN)
CHEN SHI (CN)
HU LIHONG (CN)
DING CHARLES Z (CN)
HE HAIYING (CN)
CHEN SHUHUI (CN)
CHEN SHI (CN)
HU LIHONG (CN)
DING CHARLES Z (CN)
HE HAIYING (CN)
CHEN SHUHUI (CN)
Application Number:
PCT/CN2023/091259
Publication Date:
November 02, 2023
Filing Date:
April 27, 2023
Export Citation:
Assignee:
MEDSHINE DISCOVERY INC (CN)
International Classes:
C12N15/113; A61K31/713; A61P9/12
Domestic Patent References:
| WO2021249352A1 | 2021-12-16 | |||
| WO2021110148A1 | 2021-06-10 |
Foreign References:
| CN112852809A | 2021-05-28 | |||
| US20210095290A1 | 2021-04-01 |
Other References:
MAJA M. JANAS ET AL.: "Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity", NAT COMMUN., vol. 9, 19 February 2018 (2018-02-19), XP055488485, DOI: 10.1038/s41467-018-02989-4
NAIR JAYAPRAKASH K ET AL.: "Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 136, no. 49, 10 December 2014 (2014-12-10), XP055181463, DOI: 10.1021/ja505986a
NAIR JAYAPRAKASH K ET AL.: "Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 136, no. 49, 10 December 2014 (2014-12-10), XP055181463, DOI: 10.1021/ja505986a
Attorney, Agent or Firm:
LIU , SHEN & ASSOCIATES (CN)
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