Title:
CONJUGATE OF PRIMARY AMINE AND DIOSGENIN, PREPARATION METHOD THEREFOR, AND ANTICANCER COMPOSITION COMPRISING SAME
Document Type and Number:
WIPO Patent Application WO/2017/191893
Kind Code:
A1
Abstract:
The present invention relates to a conjugate in which a primary amine is coupled to diosgenin via a linker, a preparation method therefor, and an anticancer composition comprising the same. With the introduction of a linear hydrophilic primary amine into the 3-OH position of diosgenin, the conjugate has the effect of exhibiting improved penetrability into a cancer cell membrane and thus significantly increasing in anticancer activity compared to diosgenin itself.
Inventors:
CHUN CHANGJU (KR)
CAI BANGRONG (KR)
CAI BANGRONG (KR)
Application Number:
PCT/KR2017/002368
Publication Date:
November 09, 2017
Filing Date:
March 06, 2017
Export Citation:
Assignee:
UNIV NAT CHONNAM IND FOUND (KR)
International Classes:
A61K47/50; A61K31/58; A61K31/585; A61K47/08; A61K47/18
Foreign References:
| CN104327151A | 2015-02-04 | |||
| CN104250282A | 2014-12-31 | |||
| CN104119420A | 2014-10-29 | |||
| CN101787069A | 2010-07-28 |
Other References:
JIAO, J., DIOSGENIN DOXORUBICIN : THE SYNTHESIS, CHARACTERIZATION AND ANTI-CANCER ACTIVITY OF THE DOXORUBICIN CONJUGATE WITH DIOSGENIN AS A CARRIER, vol. 2, 2015
Attorney, Agent or Firm:
WIE, Byoung-Gap (KR)
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