Title:
CONJUGATED OLIGONUCLEOTIDES
Document Type and Number:
WIPO Patent Application WO/2018/031933
Kind Code:
A3
Abstract:
Provided herein are conjugated oligonucleotides that are characterized by efficient and specific tissue distribution.
Inventors:
KHVOROVA ANASTASIA (US)
NIKAN MEHRAN (US)
HASSLER MATTHEW (US)
OSBORN MAIRE (US)
HARASZTI REKA (US)
COLES ANDREW (US)
TURANOV ANTON (US)
ARONIN NEIL (US)
BISCANS ANNABELLE (US)
NIKAN MEHRAN (US)
HASSLER MATTHEW (US)
OSBORN MAIRE (US)
HARASZTI REKA (US)
COLES ANDREW (US)
TURANOV ANTON (US)
ARONIN NEIL (US)
BISCANS ANNABELLE (US)
Application Number:
PCT/US2017/046593
Publication Date:
March 22, 2018
Filing Date:
August 11, 2017
Export Citation:
Assignee:
UNIV MASSACHUSETTS (US)
International Classes:
A61K47/00; A61K47/28; A61K48/00; C07J15/00; C07J41/00
Foreign References:
| US20150232840A1 | 2015-08-20 | |||
| US6383814B1 | 2002-05-07 | |||
| US8501706B2 | 2013-08-06 | |||
| US8507661B2 | 2013-08-13 |
Other References:
NIKAN ET AL.: "Docosahexaenoic Acid Conjugation Enhances Distribution and Safety of siRNA upon Local Administration in Mouse Brain", MOLECULAR THERAPY NUCLEIC ACIDS, vol. 5, 9 August 2016 (2016-08-09), pages e344, XP055489531
Attorney, Agent or Firm:
VELEMA, James, H. et al. (US)
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