Title:
CONJUGATED PROTEIN MONOMER SUPPORTING CORONAVIRUS PROTEIN, AGGREGATE OF SAID MONOMERS, AND COMPONENT VACCINE COMPRISING SAID AGGREGATE AS ACTIVE COMPONENT
Document Type and Number:
WIPO Patent Application WO/2021/235503
Kind Code:
A1
Abstract:
The present invention addresses the problem of establishing a means for providing a component vaccine that can elicit immunity against coronavirus, especially beta coronaviruses including the novel coronavirus (SARS-CoV-2). The inventors discovered that this problem can be solved by providing a component vaccine which comprises, as an active component, an aggregate that comprises a trimer and/or a hexamer of a molecular needle on which a structural protein of the coronavirus is supported.
Inventors:
UENO TAKAFUMI (JP)
KATAYAMA KAZUHIKO (JP)
TODAKA REIKO (JP)
SAWADA AKIHITO (JP)
HAGA KEI (JP)
KATAYAMA KAZUHIKO (JP)
TODAKA REIKO (JP)
SAWADA AKIHITO (JP)
HAGA KEI (JP)
Application Number:
PCT/JP2021/019072
Publication Date:
November 25, 2021
Filing Date:
May 19, 2021
Export Citation:
Assignee:
TOKYO INST TECH (JP)
THE KITASATO INST (JP)
THE KITASATO INST (JP)
International Classes:
C12N15/62; A61K9/12; A61K9/48; A61K38/16; A61P37/04; C07K14/165; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/50; C12N15/63
Domestic Patent References:
| WO2018074558A1 | 2018-04-26 |
Other References:
KIM E. ET AL.: "Microneedle array delivered recombinant coronavirus vaccines: Immunogenicity and rapid translational development", EBIOMEDICINE, vol. 55, 2 April 2020 (2020-04-02), pages 102743, XP055823969, DOI: 10.1016/j.ebiom.2020.102743
TAI W. ET AL.: "Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine", CELL . MOL. IMMUNOL., vol. 17, 19 March 2020 (2020-03-19), pages 613 - 620, XP037153214, DOI: 10.1038/s41423-020-0400-4
KIM YOUNG CHAN, DEMA BARBARA, REYES-SANDOVAL ARTURO: "COVID-19 vaccines: breaking record times to first-in-human trials", NPJ VACCINES, vol. 5, no. 1, 1 December 2020 (2020-12-01), XP055875164, DOI: 10.1038/s41541-020-0188-3
LIU MENGYUAN, WANG TING, ZHOU YUN, ZHAO YUTONG, ZHANG YAN, LI JIANPING: "Potential role of ACE2 in coronavirus disease 2019 (COVID-19) prevention and management", JOURNAL OF TRANSLATIONAL INTERNAL MEDICINE, vol. 8, no. 1, 1 March 2020 (2020-03-01), pages 9 - 19, XP055875166, DOI: 10.2478/jtim-2020-0003
TAI W. ET AL.: "Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine", CELL . MOL. IMMUNOL., vol. 17, 19 March 2020 (2020-03-19), pages 613 - 620, XP037153214, DOI: 10.1038/s41423-020-0400-4
KIM YOUNG CHAN, DEMA BARBARA, REYES-SANDOVAL ARTURO: "COVID-19 vaccines: breaking record times to first-in-human trials", NPJ VACCINES, vol. 5, no. 1, 1 December 2020 (2020-12-01), XP055875164, DOI: 10.1038/s41541-020-0188-3
LIU MENGYUAN, WANG TING, ZHOU YUN, ZHAO YUTONG, ZHANG YAN, LI JIANPING: "Potential role of ACE2 in coronavirus disease 2019 (COVID-19) prevention and management", JOURNAL OF TRANSLATIONAL INTERNAL MEDICINE, vol. 8, no. 1, 1 March 2020 (2020-03-01), pages 9 - 19, XP055875166, DOI: 10.2478/jtim-2020-0003
Attorney, Agent or Firm:
SHIMURA Mitsuharu (JP)
Download PDF:
Previous Patent: RESIN COMPOSITION, RUBBER COMPOSITION, RESIN MOLDED BODY, AND PRODUCTION METHOD FOR RESIN COMPOSITIO...
Next Patent: DISPOSABLE DIAPER
Next Patent: DISPOSABLE DIAPER