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Title:
CONJUGATES FOR BONE IMAGING AND BONE CANCER THERAPY
Document Type and Number:
WIPO Patent Application WO1989011877
Kind Code:
A3
Abstract:
The present invention provides conjugates formed from calcified tissues targeting agents and radiolabeled compounds. One such conjugate comprises a chelate and a targeting agent that is capable of associating with calcified tissue, wherein the chelate contains at least one nitrogen atom or at least one sulfur atom or combinations thereof as the donor atoms. Another aspect of the invention provides methods for using the conjugates for diagnostic and therapeutic purposes, including those related to bone cancer.

Inventors:
FRITZBERG ALAN R (US)
VANDERHEYDEN JEAN-LUC E (US)
KASINA SUDHAKAR (US)
FITZNER JEFFREY N (US)
Application Number:
US8902510W
Publication Date:
March 08, 1990
Filing Date:
June 08, 1989
Export Citation:
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Assignee:
NEORX CORP (US)
International Classes:
A61K51/00; A61K51/04; A61P35/00; C07F1/08; C07F1/12; C07F9/38; C07F13/00; (IPC1-7): A61K49/02; C07F13/00
Domestic Patent References:
WO1987001289A11987-03-12
Foreign References:
EP0188256A21986-07-23
US3974268A1976-08-10
EP0135160A21985-03-27
Other References:
The Journal of Nuclear Medicine, Volume 29, No. 5, May 1988, (New York, US), E.H. CHEESMAN et al.: "Technetium-99m ECD: Ester-Derivatized Diaminedithiol Tc Complexes for Imaging Brain Perfusion", page 788, No. 197
International Journal of Radiation Applications & Instrumentation, part B, Nucl. Med. Biol., Volume 14, No. 3, 1987, Pergamon Journals Ltd, (GB), A.R. KETRING: "153Sm-EDTMP and 186Re-HEDP as Bone Therapeutic Radiopharmaceuticals", pages 223-232
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