CONJUGATES OF CARBOXY POLYSACCHARIDES WITH FIBROBLAST GROWTH FACTORS AND VARIANTS THEREOF

Title:

CONJUGATES OF CARBOXY POLYSACCHARIDES WITH FIBROBLAST GROWTH FACTORS AND VARIANTS THEREOF

Document Type and Number:

WIPO Patent Application WO/2012/140650

Kind Code:

A3

Abstract:

The present invention relates to conjugates of hydrophilic carboxy polysaccharides with protein members of the fibroblast growth factor (FGF) family and variants thereof. The conjugates provide a modified bioactivity and stability of FGFs for various therapeutic applications.

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Inventors:

YAYON AVNER (IL)
SIRKIS ROY (IL)
AMIT BOAZ (IL)
WORTZEL AVRAHAM (IL)

Application Number:

PCT/IL2012/000158

Publication Date:

May 10, 2013

Filing Date:

April 05, 2012

Export Citation:

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Assignee:

HEPACORE LTD (IL)
YAYON AVNER (IL)
SIRKIS ROY (IL)
AMIT BOAZ (IL)
WORTZEL AVRAHAM (IL)

International Classes:

A61K47/48

Foreign References:

US20100086594A1	2010-04-08
US20110053841A1	2011-03-03
US20100125049A1	2010-05-20

Other References:

KANG ET AL.: "Poly(ethylene glycol) modification enhances penetration of fibroblast growth factor 2 to injured spinal cord tissue from an intrathecal delivery system", JOURNAL OF CONTROLLED RELEASE, vol. 144, 28 January 2010 (2010-01-28), pages 25 - 31, XP027036552
YAMAGUCHI ET AL.: "Polysaccharide-Poly(ethylene glycol) Star Copolymer as a Scaffold for the Production of Bioactive Hydrogels", BIOMACROMOLECULES, vol. 6, no. ISS. 4, 1 July 2005 (2005-07-01), pages 1921 - 1930, XP002539059, DOI: doi:10.1021/BM050003

Attorney, Agent or Firm:

WEBB & CO. et al. (Rehovot, IL)

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