Title:
CONJUGATES OF CHEMOTHERAPY AGENTS AND TISSUE-BINDING SMALL MOLECULES, COMPOSITIONS AND METHODS THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/151513
Kind Code:
A1
Abstract:
The invention provides novel conjugates of tissue-binding small molecules and therapeutic agents and pharmaceutical compositions thereof, and their use in and methods of treatment of certain diseases or conditions (e.g., cancer).
Inventors:
YU NINGHUI (CN)
LOU RONGLIANG (CN)
LOU RONGLIANG (CN)
Application Number:
PCT/CN2023/074329
Publication Date:
August 17, 2023
Filing Date:
February 03, 2023
Export Citation:
Assignee:
CANWELL BIOTECH LTD (CN)
International Classes:
C07D491/22; A61K31/282; A61K31/4745; A61K31/513; A61K31/519; A61K31/69; A61P35/00; A61P43/00; C07D239/52; C07D471/04; C07F5/02; C07F15/00
Domestic Patent References:
| WO2002056885A1 | 2002-07-25 |
Foreign References:
| KR101990214B1 | 2019-06-17 | |||
| CN109675050A | 2019-04-26 |
Other References:
YANG XUE‐YAN, ZHAO HONG‐YI, LEI HAO, YUAN BO, MAO SHUAI, XIN MINGHANG, ZHANG SAN‐QI: "Synthesis and Biological Evaluation of 10‐Substituted Camptothecin Derivatives with Improved Water Solubility and Activity", CHEMMEDCHEM COMMUNICATIONS, WILEY-VCH, DE, vol. 16, no. 6, 18 March 2021 (2021-03-18), DE , pages 1000 - 1010, XP093082715, ISSN: 1860-7179, DOI: 10.1002/cmdc.202000753
LV JIAN, GUO NA, WEN SHAO-PENG, TENG YU-OU, MA MENG-XIN, YU PENG: "Synthesis and antitumor activity evaluation of a novel series of camptothecin analogs", JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, GORDON AND BREACH, CHUR, CH, vol. 15, no. 8, 1 August 2013 (2013-08-01), CH , pages 867 - 874, XP093082716, ISSN: 1028-6020, DOI: 10.1080/10286020.2013.804068
LV JIAN, GUO NA, WEN SHAO-PENG, TENG YU-OU, MA MENG-XIN, YU PENG: "Synthesis and antitumor activity evaluation of a novel series of camptothecin analogs", JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, GORDON AND BREACH, CHUR, CH, vol. 15, no. 8, 1 August 2013 (2013-08-01), CH , pages 867 - 874, XP093082716, ISSN: 1028-6020, DOI: 10.1080/10286020.2013.804068
Attorney, Agent or Firm:
SHENZHEN ZHONGDING INTELLECTUAL PROPERTY AGENCY (CN)
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