CONJUGATES COMPRISING A BIODEGRADABLE POLYMER AND USES THEREFOR

WIPO Patent Application WO2003070823

A3

The present invention provides biologically active agents covalently linked to a polymer. The polymer is preferably a biodegradable polymer. The biologically active agent is preferably a protein, such as an extracellular soluble protein, e.g., an extracellular enzyme. The enzyme can be an apyrase, e.g., NTPDase. Conjugates of the invention can be used as therapeutics in subjects. For example, a conjugate comprising an apyrase can be used for treating and preventing thrombosis, atherosclerotic plaque complications and vascular disorders.

ELMALEH DAVID R (US)
ROBSON SIMON C (US)
PAPISOV MIKHAIL I (US)

PCT/US2003/004845

August 26, 2004

February 19, 2003

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GEN HOSPITAL CORP (US)
BETH ISRAEL HOSPITAL (US)
ELMALEH DAVID R (US)
ROBSON SIMON C (US)
PAPISOV MIKHAIL I (US)

A61K31/74; A61K38/46; A61K47/48; C08L59/00; C12N11/08; (IPC1-7): C12N9/96; C12N9/00; C12N9/14; C12N11/02; C12N11/10; C12N11/12; C07K1/00

US5221495A	1993-06-22
US5240843A	1993-08-31
US4729956A	1988-03-08

DRAGO ET AL: "Enzyme Stability and Stabilisation: Application and Case Studies, Focus on Biotechnology", ENGINEERING AND MANUFACTURING FOR BIOTECHNOLOGY, 2001, pages 361 - 376, XP002978413
KACZMAREK ET AL: "Identification and Characterization of CD39/Vascular ATP Diphosphohydrolase", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 51, December 1996 (1996-12-01), pages 33116 - 33122, XP002934573

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