CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LIKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS

Title:

CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LIKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS

Document Type and Number:

WIPO Patent Application WO/2018/086139

Kind Code:

A1

Abstract:

The present invention relates to linkers having a group of propiolyl, substituted acryl (acryloyl), or disubstituted propanoyl, and using such linkers for the conjugation of compounds, in particular, cytotoxic agents to a cell-binding molecule.

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Inventors:

ZHAO YONGXIN ROBERT (CN)
YANG QINGLIANG (CN)
HUANG YUANYUAN (CN)
GAI SHUN (CN)
YE HANGBO (CN)
ZHAO LINYAO (CN)
YANG CHENGYU (CN)
GUO HUIHUI (CN)
ZHOU XIAOMAI (CN)
XIE HONGSHENG (CN)
ZHU HAIFENG (CN)
XU YIFANG (CN)
TONG QIANQIAN (CN)
JIA JUNXIANG (CN)
CAO MINJUN (CN)
LI WENJUN (CN)
GAO SHUIHONG (CN)
GUO ZHIXIANG (CN)
BAI LU (CN)
LI CHEN (CN)
YANG YANLEI (CN)
WANG CHUNYAN (CN)
YE ZHICHANG (CN)

Application Number:

PCT/CN2016/105799

Publication Date:

May 17, 2018

Filing Date:

November 14, 2016

Export Citation:

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Assignee:

HANGZHOU DAC BIOTECH CO LTD (CN)
SUZHOU M CONJI BIOTECH CO LTD (CN)

International Classes:

A61K31/10

Foreign References:

CN105849086A	2016-08-10
US20150314017A1	2015-11-05
CN105641707A	2016-06-08
KR20150023563A	2015-03-05
EP1838332A1	2007-10-03

Other References: