Title:
CONOTOXIN POLYPEPTIDE Κ-CPTX-BT103, AND METHOD FOR PREPARATION THEREOF AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/049873
Kind Code:
A1
Abstract:
Provided are a conotoxin polypeptide κ-CPTx-bt103, a method for preparation thereof, and an application thereof. The conotoxin polypeptide consists of 29 amino acids, has a molecular weight of 3141.43 daltons, and has the full sequence RTNCGETCLKDEQCVGACQICVPSQLKCL. The conotoxin polypeptide has a potassium ion channel current-suppression effect and an analgesic effect, and may be used for drug development and clinical applications to treat pain, epilepsy, stroke, convulsions, muscle relaxation, Parkinson's disease, Alzheimer's disease, depression, addiction, cardiovascular disease, cancer, inflammation, and other diseases.
Inventors:
LIN ZHILONG (CN)
WEN BO (CN)
TONG TING (CN)
LIU JIE (CN)
DU CHAOQIN (CN)
MO FEN (CN)
PENG CHAO (CN)
SHI QIONG (CN)
WEN BO (CN)
TONG TING (CN)
LIU JIE (CN)
DU CHAOQIN (CN)
MO FEN (CN)
PENG CHAO (CN)
SHI QIONG (CN)
Application Number:
PCT/CN2014/087983
Publication Date:
April 07, 2016
Filing Date:
September 30, 2014
Export Citation:
Assignee:
BGI SHENZHEN CO LTD (CN)
International Classes:
A61P1/06; C07K14/435; A61P9/00; A61P21/00; A61P25/08; A61P25/16; A61P25/24; A61P25/28; A61P25/30; A61P29/00; A61P35/00; C07K1/14; C07K1/18
Foreign References:
| CN1796412A | 2006-07-05 | |||
| CN1796413A | 2006-07-05 |
Other References:
DATABASE NCBI 1 October 2013 (2013-10-01), "P-Conotoxin Peptide Precursor Fla9.1, Partial [Conus Flavidus].", Database accession no. AFU50766.1
ZHAO, TINGYOU ET AL.: "Purification, Sequence and Disulfide Bonding Pattern of a Novel Conotoxin BtIIIB", ACTA CHIMICA SINICA, vol. 63, no. 2, 31 December 2005 (2005-12-31), pages 163 - 168, XP008184306
ZHU, CUI ET AL.: "Progress on the Study of New Superfamily Conotoxins", CHINESE JOURNAL OF MARINE DRUGS, vol. 33, no. 2, 30 April 2014 (2014-04-30), pages 84 - 9, XP008184324
DAI, XIANDONG ET AL.: "Isolation and Characterization of Conotoxin bt5a from Conus Betulinus", CHINESE JOURNAL OF NATURAL MEDICINES, vol. 8, no. 2, 20 March 2010 (2010-03-20), pages 132 - 136, XP027011995
CONTICELLO, S.G. ET AL.: "Mechanisms for Evolving Hypervariability: the Case of Conopeptides.", MOL. BIOL. EVOL., vol. 18, no. 2, 31 December 2001 (2001-12-31), pages 120 - 131, XP001179421
WU, YONG ET AL.: "Synthesis and Bioactivity of T-superfamily Conotoxin B8.1T Native to Hainan", BIOTECHNOLOGY BULLETIN, no. 7, 31 December 2013 (2013-12-31), pages 184 - 188, XP055366175
See also references of EP 3202782A4
ZHAO, TINGYOU ET AL.: "Purification, Sequence and Disulfide Bonding Pattern of a Novel Conotoxin BtIIIB", ACTA CHIMICA SINICA, vol. 63, no. 2, 31 December 2005 (2005-12-31), pages 163 - 168, XP008184306
ZHU, CUI ET AL.: "Progress on the Study of New Superfamily Conotoxins", CHINESE JOURNAL OF MARINE DRUGS, vol. 33, no. 2, 30 April 2014 (2014-04-30), pages 84 - 9, XP008184324
DAI, XIANDONG ET AL.: "Isolation and Characterization of Conotoxin bt5a from Conus Betulinus", CHINESE JOURNAL OF NATURAL MEDICINES, vol. 8, no. 2, 20 March 2010 (2010-03-20), pages 132 - 136, XP027011995
CONTICELLO, S.G. ET AL.: "Mechanisms for Evolving Hypervariability: the Case of Conopeptides.", MOL. BIOL. EVOL., vol. 18, no. 2, 31 December 2001 (2001-12-31), pages 120 - 131, XP001179421
WU, YONG ET AL.: "Synthesis and Bioactivity of T-superfamily Conotoxin B8.1T Native to Hainan", BIOTECHNOLOGY BULLETIN, no. 7, 31 December 2013 (2013-12-31), pages 184 - 188, XP055366175
See also references of EP 3202782A4
Attorney, Agent or Firm:
SHENZHEN KEJIN INTELLECTUAL PROPERTY OFFICE (CN)
深圳市科进知识产权代理事务所(普通合伙) (CN)
深圳市科进知识产权代理事务所(普通合伙) (CN)
Download PDF:
Previous Patent: DEVICE AND METHOD FOR MEASURING NETWORK PACKET LOSS
Next Patent: MULTIPLE CHANNEL ACCESS METHOD AND DEVICE
Next Patent: MULTIPLE CHANNEL ACCESS METHOD AND DEVICE