Title:
CONSTRUCTION OF ARTERIAL OCCLUSIVE DISEASE ANIMAL MODEL
Document Type and Number:
WIPO Patent Application WO/2006/030737
Kind Code:
A1
Abstract:
A method of constructing a nonhuman animal model of an arterial occlusive disease characterized by blocking the artery by ligating at a specific site or forming an autologous blood clot. In particular, a method of constructing a myocardial infarction model characterized by comprising ligating a blood vessel of a nonhuman test animal in the downstream of the cardioarterial part to be blocked and then blocking the artery at the site to be blocked; a kit therefor; and a myocardial infarction animal model obtained by using the method or the kit. A method of constructing an arterial occlusion nonhuman animal model characterized by comprising adding a coagulating agent to the autologous blood of an animal to form an autologous blood clot and then delivering the autologous blood clot into the artery with the use of an angiographic device; a system therefor; and an arterial occlusion animal model obtained by using the method or the system.
Inventors:
IIDA HIDEHIRO (JP)
OHTA YOICHIRO (JP)
TERAMOTO NOBORU (JP)
HAYASHI TAKUYA (JP)
OHTA YOICHIRO (JP)
TERAMOTO NOBORU (JP)
HAYASHI TAKUYA (JP)
Application Number:
PCT/JP2005/016756
Publication Date:
March 23, 2006
Filing Date:
September 12, 2005
Export Citation:
Assignee:
JAPAN HEALTH SCIENCE FOUND (JP)
IIDA HIDEHIRO (JP)
OHTA YOICHIRO (JP)
TERAMOTO NOBORU (JP)
HAYASHI TAKUYA (JP)
IIDA HIDEHIRO (JP)
OHTA YOICHIRO (JP)
TERAMOTO NOBORU (JP)
HAYASHI TAKUYA (JP)
International Classes:
A01K67/027; A01K67/00; A61B6/00; A61D7/00; G01T1/161
Other References:
KOMURO H.: "Junkanki Shikkan no Saisei Iryo", UEHARA MEMORIAL FOUNDATION KENKYU HOKOKU, vol. 17, 2003, pages 352 - 356, XP002999854
HARADA K. ET AL: "Basic fibroblast growth factor improves myocardial function in chronically ischemic porcine hearts", J.CLIN.INVEST., vol. 94, 1994, pages 623 - 630, XP002043081
KAWAMOTO A. ET AL: "Intramyocardial transplantation of autologous endothelial progenitor cells for therapeutic neovascularization of myocardial ischemia", CIRCULATION, vol. 107, 2003, pages 461 - 468, XP002999855
See also references of EP 1808071A4
SAITO 1; FOLSOM AR; AONO H; OZAWA H; IKEBE T; YAMASHITA T: "Comparison of fatal coronary heart disease occurrence based on population surveys in Japan and the USA", INT J EPIDEMIOL., vol. 29, 2000, pages 837 - 844
BALADY GJ; JETTE D; SCHEER J; DOWNING J: "Changes in exercise capacity following cardiac rehabilitation in patients stratified according to age and gender. Results of the Massachusetts Association of Cardiovascular and Pulmonary Rehabilitation Multicenter Database", J CARDIOPULM REHABIL., vol. 16, 1996, pages 38 - 46
KRUM H; HAAS SJ; EICHHORN E; GHALI J; GILBERT E; LECHAT P; PACKER M; ROECKER E; VERKENNE P; WEDEL H: "Prognostic benefit of beta- blockers in patients not receiving ACE-Inhibitors", EUR HEART J., vol. 26, 2005, pages 2154 - 2158
ANVERSA P; LERI A; KAJSTURA J: "Cardiac regeneration", J AM CALL CARDIOL., vol. 47, 2006, pages 1769 - 1776
GHEERAERT PJ; HENRIQUES JP; DE BUYZERE ML; DE PAUW M; TAEYMANS Y; ZIJLSTRA F: "Preinfarction angina protects against out-of-hospital ventricular fibrillation in patients with acute occlusion of the left coronary artery", J AM COLL CARDIOL., vol. 38, 2001, pages 1369 - 1374
MILLARD RW: "Induction of functional coronary collaterals in the swine heart", BASIC RES CARDIOL., vol. 76, 1981, pages 468 - 473
ROTH DM; MARUOKA Y; ROGERS J; WHITE FC; LONGHURST JC; BLOOR CM: "Development of coronary collateral circulation in left circumflex Ameroid- occluded swine myocardium", AM J PHYSIOL., vol. 253, 1987, pages H1279 - 1288
FALLAVOLLITA JA; RIEGEL BJ; SUZUKI G; VALETI U; CANTY JM, JR.: "Mechanism of sudden cardiac death in pigs with viable chronically dysfunctional myocardium and ischemic cardiomyopathy", AM J PHYSIOL HEART CIRC PHYSIOL., vol. 289, 2005, pages H2688 - 2696
CANTY JM, JR.; SUZUKI G; BANAS MD; VERHEYEN F; BORGERS M; FALLAVOLLITA JA: "Hibernating myocardium: chronically adapted to ischemia but vulnerable to sudden death", CIRC RES., vol. 94, 2004, pages 1142 - 1149
FALLAVOLLITA JA; CANTY JM, JR.: "Differential 18F-2-deoxyglucose uptake in viable dysfunctional myocardium with normal resting perfusion: evidence for chronic stunning in pigs", CIRCULATION, vol. 99, 1999, pages 2798 - 2805
FALLAVOLLITA JA; CANTY JM, JR.: "Ischemic cardiomyopathy in pigs with two- vessel occlusion and viable, chronically dysfunctional myocardium", AM J PHYSIOL HEART CIRC PHYSIOL., vol. 282, 2002, pages H1370 - 1379
FALLAVOLLITA JA; LOGUE M; CANTY JM, JR.: "Stability of hibernating myocardium in pigs with a chronic left anterior descending coronary artery stenosis: absence of progressive fibrosis in the setting of stable reductions in flow, function and coronary flow reserve", J AM CO// CARDIOL., vol. 37, 2001, pages 1989 - 1995
SHEN YT; VATNER SF: "Mechanism of impaired myocardial function during progressive coronary stenosis in conscious pigs. Hibernation versus stunning", CIRC RES., vol. 76, 1995, pages 479 - 488
MILLS I; FALLON JT; WRENN D; SASKEN H; GRAY W; BIER J; LEVINE D; BERMAN S; GILSON M; GEWIRTZ H: "Adaptive responses of coronary circulation and myocardium to chronic reduction in perfusion pressure and flow", AM J PHYSIOL., vol. 266, 1994, pages H447 - 457
ROTH DM; WHITE FC; NICHOLS ML; DOBBS SL; LONGHURST JC; BLOOR CM: "Effect of long-term exercise on regional myocardial function and coronary collateral development after gradual coronary artery occlusion in pigs", CIRCULATION, vol. 82, 1990, pages 1778 - 1789
KITAKAZE M; NODE K; MINAMINO T; KOMAMURA K; FUNAYA H; SHINOZAKI Y; CHUJO M; MORI H; INOUE M; HORI M: "Role of activation of protein kinase C in the infarct size-limiting effect of ischemic preconditioning through activation of ecto-5'-nucleotidase", CIRCULATION, vol. 93, 1996, pages 781 - 791
KHARBANDA RK; MORTENSEN UM; WHITE PA; KRISTIANSEN SB; SCHMIDT MR; HOSCHTITZKY JA; VOGEL M; SORENSEN K; REDINGTON AN; MACALLISTER R: "Transient limb ischemia induces remote ischemic preconditioning in vivo", CIRCULATION, vol. 106, 2002, pages 2881 - 2883
CHEN PS; CHEN LS; CAO JM; SHARIFI B; KARAGUEUZIAN HS; FISHBEIN MC: "Sympathetic nerve sprouting, electrical remodeling and the mechanisms of sudden cardiac death", CARDIOVASC RES., vol. 50, 2001, pages 409 - 416
MOSES MA; ADDISON PD; NELIGAN PC; ASHRAFPOUR H; HUANG N; MCALLISTER SE; LIPA JE; FORREST CR; PANG CY: "Inducing late phase of infarct protection in skeletal muscle by remote preconditioning: efficacy and mechanism", AM J PHYSIOL REGUL INTEGR COMP PHYSIOL., vol. 289, 2005, pages R1609 - 1617
O'KONSKI MS; WHITE FC; LONGHURST J; ROTH D; BLOOR CM: "Ameroid constriction of the proximal left circumflex coronary artery in swine. A model of limited coronary collateral circulation", AM J CARDIOVASC PATHOL., vol. 1, 1987, pages 69 - 77
LIDA H; TAKAHASHI A; TAMURA Y; ONO Y; LAMMERTSMA AA: "Myocardial blood flow: comparison of oxygen-15-water bolus injection, slow infusion and oxygen-15-carbon dioxide slow inhalation", J NUCL MED., vol. 36, 1995, pages 78 - 85
DEFRONZO RA; TOBIN JD; ANDRES R: "Glucose clamp technique: a method for quantifying insulin secretion and resistance", AM J PHYSIOL., vol. 237, 1979, pages E214 - 223
KNUUTI MJ; NUUTILA P; RUOTSALAINEN U; SARASTE M; HARKONEN R; AHONEN A; TERAS M; HAAPARANTA M; WEGELIUS U; HAAPANEN A: "Euglycemic hyperinsulinemic clamp and oral glucose load in stimulating myocardial glucose utilization during positron emission tomography", J NUCL MED., vol. 33, 1992, pages 1255 - 1262
LIDA H; RHODES CG; DE SILVA R; YAMAMOTO Y; ARAUJO LI; MASERI A; JONES T: "Myocardial tissue fraction--correction for partial volume effects and measure of tissue viability", J NUCL MED., vol. 32, 1991, pages 2169 - 2175
LIDA H; TAMURA Y; KITAMURA K; BLOOMFIELD PM; EBERL S; ONO Y: "Histochemical correlates of (15)O-water-perfusable tissue fraction in experimental canine studies of old myocardial infarction", J NUCL MED., vol. 41, 2000, pages 1737 - 1745
LIDA H; RHODES CG; DE SILVA R; ARAUJO LI; BLOOMFIELD PM; LAMMERTSMA AA; JONES T: "Use of the left ventricular time-activity curve as a noninvasive input function in dynamic oxygen-15-water positron emission tomography", J NUCL MED., vol. 33, 1992, pages 1669 - 1677
DE SILVA R; YAMAMOTO Y; RHODES CG; LIDA H; NIHOYANNOPOULOS P; DAVIES GJ; LAMMERTSMA AA; JONES T; MASERI A: "Preoperative prediction of the outcome of coronary revascularization using positron emission tomography", CIRCULATION, vol. 86, 1992, pages 1738 - 1742
YAMAMOTO Y; DE SILVA R; RHODES CG; ARAUJO LI; LIDA H; RECHAVIA E; NIHOYANNOPOULOS P; HACKETT D; GALASSI AR; TAYLOR CJ: "A new strategy for the assessment of viable myocardium and regional myocardial blood flow using 150-water and dynamic positron emission tomography", CIRCULATION, vol. 86, 1992, pages 167 - 178
KNAAPEN P; BOELLAARD R; GOTTE MJ; DIJKMANS PA; VAN CAMPEN LM; DE COCK CC; LUURTSEMA G; VISSER CA; LAMMERTSMA AA; VISSER FC: "Perfusable tissue index as a potential marker of fibrosis in patients with idiopathic dilated cardiomyopathy", J NUCL MED., vol. 45, 2004, pages 1299 - 1304
KNAAPEN P; BOELLAARD R; GOTTE MJ; VAN DER WEERDT AP; VISSER CA; LAMMERTSMA AA; VISSER FC: "The perfusable tissue index: a marker of myocardial viability", J NUCL CARDIOL., vol. 10, 2003, pages 684 - 691
KNAAPEN P; BONDARENKO O; BEEK AM; GOTTE MJ; BOELLAARD R; VAN DER WEERDT AP; VISSER CA; VAN ROSSUM AC; LAMMERTSMA AA; VISSER FC: "Impact of Scar on Water-Perfusable Tissue Index in Chronic Ischemic Heart Disease : Evaluation with PET and Contrast-Enhanced MRI", MOL IMAGING BIOL., 2006
KNAAPEN P; VAN DOCKUM WG; BONDARENKO O; KOK WE; GOTTE MJ; BOELLAARD R; BEEK AM; VISSER CA; VAN ROSSUM AC; LAMMERTSMA AA: "Delayed contrast enhancement and perfusable tissue index in hypertrophic cardiomyopathy: comparison between cardiac MRI and PET", J NUCL MED., vol. 46, 2005, pages 923 - 929
HARADA K. ET AL: "Basic fibroblast growth factor improves myocardial function in chronically ischemic porcine hearts", J.CLIN.INVEST., vol. 94, 1994, pages 623 - 630, XP002043081
KAWAMOTO A. ET AL: "Intramyocardial transplantation of autologous endothelial progenitor cells for therapeutic neovascularization of myocardial ischemia", CIRCULATION, vol. 107, 2003, pages 461 - 468, XP002999855
See also references of EP 1808071A4
SAITO 1; FOLSOM AR; AONO H; OZAWA H; IKEBE T; YAMASHITA T: "Comparison of fatal coronary heart disease occurrence based on population surveys in Japan and the USA", INT J EPIDEMIOL., vol. 29, 2000, pages 837 - 844
BALADY GJ; JETTE D; SCHEER J; DOWNING J: "Changes in exercise capacity following cardiac rehabilitation in patients stratified according to age and gender. Results of the Massachusetts Association of Cardiovascular and Pulmonary Rehabilitation Multicenter Database", J CARDIOPULM REHABIL., vol. 16, 1996, pages 38 - 46
KRUM H; HAAS SJ; EICHHORN E; GHALI J; GILBERT E; LECHAT P; PACKER M; ROECKER E; VERKENNE P; WEDEL H: "Prognostic benefit of beta- blockers in patients not receiving ACE-Inhibitors", EUR HEART J., vol. 26, 2005, pages 2154 - 2158
ANVERSA P; LERI A; KAJSTURA J: "Cardiac regeneration", J AM CALL CARDIOL., vol. 47, 2006, pages 1769 - 1776
GHEERAERT PJ; HENRIQUES JP; DE BUYZERE ML; DE PAUW M; TAEYMANS Y; ZIJLSTRA F: "Preinfarction angina protects against out-of-hospital ventricular fibrillation in patients with acute occlusion of the left coronary artery", J AM COLL CARDIOL., vol. 38, 2001, pages 1369 - 1374
MILLARD RW: "Induction of functional coronary collaterals in the swine heart", BASIC RES CARDIOL., vol. 76, 1981, pages 468 - 473
ROTH DM; MARUOKA Y; ROGERS J; WHITE FC; LONGHURST JC; BLOOR CM: "Development of coronary collateral circulation in left circumflex Ameroid- occluded swine myocardium", AM J PHYSIOL., vol. 253, 1987, pages H1279 - 1288
FALLAVOLLITA JA; RIEGEL BJ; SUZUKI G; VALETI U; CANTY JM, JR.: "Mechanism of sudden cardiac death in pigs with viable chronically dysfunctional myocardium and ischemic cardiomyopathy", AM J PHYSIOL HEART CIRC PHYSIOL., vol. 289, 2005, pages H2688 - 2696
CANTY JM, JR.; SUZUKI G; BANAS MD; VERHEYEN F; BORGERS M; FALLAVOLLITA JA: "Hibernating myocardium: chronically adapted to ischemia but vulnerable to sudden death", CIRC RES., vol. 94, 2004, pages 1142 - 1149
FALLAVOLLITA JA; CANTY JM, JR.: "Differential 18F-2-deoxyglucose uptake in viable dysfunctional myocardium with normal resting perfusion: evidence for chronic stunning in pigs", CIRCULATION, vol. 99, 1999, pages 2798 - 2805
FALLAVOLLITA JA; CANTY JM, JR.: "Ischemic cardiomyopathy in pigs with two- vessel occlusion and viable, chronically dysfunctional myocardium", AM J PHYSIOL HEART CIRC PHYSIOL., vol. 282, 2002, pages H1370 - 1379
FALLAVOLLITA JA; LOGUE M; CANTY JM, JR.: "Stability of hibernating myocardium in pigs with a chronic left anterior descending coronary artery stenosis: absence of progressive fibrosis in the setting of stable reductions in flow, function and coronary flow reserve", J AM CO// CARDIOL., vol. 37, 2001, pages 1989 - 1995
SHEN YT; VATNER SF: "Mechanism of impaired myocardial function during progressive coronary stenosis in conscious pigs. Hibernation versus stunning", CIRC RES., vol. 76, 1995, pages 479 - 488
MILLS I; FALLON JT; WRENN D; SASKEN H; GRAY W; BIER J; LEVINE D; BERMAN S; GILSON M; GEWIRTZ H: "Adaptive responses of coronary circulation and myocardium to chronic reduction in perfusion pressure and flow", AM J PHYSIOL., vol. 266, 1994, pages H447 - 457
ROTH DM; WHITE FC; NICHOLS ML; DOBBS SL; LONGHURST JC; BLOOR CM: "Effect of long-term exercise on regional myocardial function and coronary collateral development after gradual coronary artery occlusion in pigs", CIRCULATION, vol. 82, 1990, pages 1778 - 1789
KITAKAZE M; NODE K; MINAMINO T; KOMAMURA K; FUNAYA H; SHINOZAKI Y; CHUJO M; MORI H; INOUE M; HORI M: "Role of activation of protein kinase C in the infarct size-limiting effect of ischemic preconditioning through activation of ecto-5'-nucleotidase", CIRCULATION, vol. 93, 1996, pages 781 - 791
KHARBANDA RK; MORTENSEN UM; WHITE PA; KRISTIANSEN SB; SCHMIDT MR; HOSCHTITZKY JA; VOGEL M; SORENSEN K; REDINGTON AN; MACALLISTER R: "Transient limb ischemia induces remote ischemic preconditioning in vivo", CIRCULATION, vol. 106, 2002, pages 2881 - 2883
CHEN PS; CHEN LS; CAO JM; SHARIFI B; KARAGUEUZIAN HS; FISHBEIN MC: "Sympathetic nerve sprouting, electrical remodeling and the mechanisms of sudden cardiac death", CARDIOVASC RES., vol. 50, 2001, pages 409 - 416
MOSES MA; ADDISON PD; NELIGAN PC; ASHRAFPOUR H; HUANG N; MCALLISTER SE; LIPA JE; FORREST CR; PANG CY: "Inducing late phase of infarct protection in skeletal muscle by remote preconditioning: efficacy and mechanism", AM J PHYSIOL REGUL INTEGR COMP PHYSIOL., vol. 289, 2005, pages R1609 - 1617
O'KONSKI MS; WHITE FC; LONGHURST J; ROTH D; BLOOR CM: "Ameroid constriction of the proximal left circumflex coronary artery in swine. A model of limited coronary collateral circulation", AM J CARDIOVASC PATHOL., vol. 1, 1987, pages 69 - 77
LIDA H; TAKAHASHI A; TAMURA Y; ONO Y; LAMMERTSMA AA: "Myocardial blood flow: comparison of oxygen-15-water bolus injection, slow infusion and oxygen-15-carbon dioxide slow inhalation", J NUCL MED., vol. 36, 1995, pages 78 - 85
DEFRONZO RA; TOBIN JD; ANDRES R: "Glucose clamp technique: a method for quantifying insulin secretion and resistance", AM J PHYSIOL., vol. 237, 1979, pages E214 - 223
KNUUTI MJ; NUUTILA P; RUOTSALAINEN U; SARASTE M; HARKONEN R; AHONEN A; TERAS M; HAAPARANTA M; WEGELIUS U; HAAPANEN A: "Euglycemic hyperinsulinemic clamp and oral glucose load in stimulating myocardial glucose utilization during positron emission tomography", J NUCL MED., vol. 33, 1992, pages 1255 - 1262
LIDA H; RHODES CG; DE SILVA R; YAMAMOTO Y; ARAUJO LI; MASERI A; JONES T: "Myocardial tissue fraction--correction for partial volume effects and measure of tissue viability", J NUCL MED., vol. 32, 1991, pages 2169 - 2175
LIDA H; TAMURA Y; KITAMURA K; BLOOMFIELD PM; EBERL S; ONO Y: "Histochemical correlates of (15)O-water-perfusable tissue fraction in experimental canine studies of old myocardial infarction", J NUCL MED., vol. 41, 2000, pages 1737 - 1745
LIDA H; RHODES CG; DE SILVA R; ARAUJO LI; BLOOMFIELD PM; LAMMERTSMA AA; JONES T: "Use of the left ventricular time-activity curve as a noninvasive input function in dynamic oxygen-15-water positron emission tomography", J NUCL MED., vol. 33, 1992, pages 1669 - 1677
DE SILVA R; YAMAMOTO Y; RHODES CG; LIDA H; NIHOYANNOPOULOS P; DAVIES GJ; LAMMERTSMA AA; JONES T; MASERI A: "Preoperative prediction of the outcome of coronary revascularization using positron emission tomography", CIRCULATION, vol. 86, 1992, pages 1738 - 1742
YAMAMOTO Y; DE SILVA R; RHODES CG; ARAUJO LI; LIDA H; RECHAVIA E; NIHOYANNOPOULOS P; HACKETT D; GALASSI AR; TAYLOR CJ: "A new strategy for the assessment of viable myocardium and regional myocardial blood flow using 150-water and dynamic positron emission tomography", CIRCULATION, vol. 86, 1992, pages 167 - 178
KNAAPEN P; BOELLAARD R; GOTTE MJ; DIJKMANS PA; VAN CAMPEN LM; DE COCK CC; LUURTSEMA G; VISSER CA; LAMMERTSMA AA; VISSER FC: "Perfusable tissue index as a potential marker of fibrosis in patients with idiopathic dilated cardiomyopathy", J NUCL MED., vol. 45, 2004, pages 1299 - 1304
KNAAPEN P; BOELLAARD R; GOTTE MJ; VAN DER WEERDT AP; VISSER CA; LAMMERTSMA AA; VISSER FC: "The perfusable tissue index: a marker of myocardial viability", J NUCL CARDIOL., vol. 10, 2003, pages 684 - 691
KNAAPEN P; BONDARENKO O; BEEK AM; GOTTE MJ; BOELLAARD R; VAN DER WEERDT AP; VISSER CA; VAN ROSSUM AC; LAMMERTSMA AA; VISSER FC: "Impact of Scar on Water-Perfusable Tissue Index in Chronic Ischemic Heart Disease : Evaluation with PET and Contrast-Enhanced MRI", MOL IMAGING BIOL., 2006
KNAAPEN P; VAN DOCKUM WG; BONDARENKO O; KOK WE; GOTTE MJ; BOELLAARD R; BEEK AM; VISSER CA; VAN ROSSUM AC; LAMMERTSMA AA: "Delayed contrast enhancement and perfusable tissue index in hypertrophic cardiomyopathy: comparison between cardiac MRI and PET", J NUCL MED., vol. 46, 2005, pages 923 - 929
Attorney, Agent or Firm:
Kawamiya, Osamu (IMP Building 3-7, Shiromi 1-chome, Chuo-k, Osaka-shi Osaka, JP)
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