Title:
CONSTRUCTION OF H-GENE-REPLACED CHIMERIC MEASLES ATTENUATED STRAIN
Document Type and Number:
WIPO Patent Application WO/2022/188784
Kind Code:
A1
Abstract:
Provided are a construction method for an H-gene-replaced chimeric measles attenuated strain and an application thereof. The attenuated strain is a measles virus rMV/H(H1a) having an accession number of CCTCCNO: V202074. Further provided are a vaccine composition containing the H-gene-replaced chimeric measles attenuated strain or a derivative virus strain thereof as an active ingredient, and a preparation method therefor.
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Inventors:
AN QI (CN)
ZHU FENGCAI (CN)
TIAN DAYONG (CN)
XIE LIXIA (CN)
ZHU FENGCAI (CN)
TIAN DAYONG (CN)
XIE LIXIA (CN)
Application Number:
PCT/CN2022/079777
Publication Date:
September 15, 2022
Filing Date:
March 08, 2022
Export Citation:
Assignee:
SHANGHAI KING CELL BIOTECHNOLOGY CO LTD (CN)
BEIJING CELL FUSION BIOTECHNOLOGY CO LTD (CN)
BEIJING CELL FUSION BIOTECHNOLOGY CO LTD (CN)
International Classes:
C12N7/04; A61K39/155; A61P31/14; C07K14/12; C12N15/45; C12R1/93
Domestic Patent References:
| WO2009152969A1 | 2009-12-23 |
Foreign References:
| CN113293148A | 2021-08-24 | |||
| CN113999824A | 2022-02-01 | |||
| CN101323857A | 2008-12-17 | |||
| CN1662553A | 2005-08-31 | |||
| CN103200947A | 2013-07-10 | |||
| CN111100845A | 2020-05-05 |
Other References:
ZHANG YONGXIA, LI MEIYING;CHEN ZONGXIANG;LI ZHUSHI;YANG XIAOYONG;FAN FENGMING;LIU LANJUN: "Construction of a Reverse-Genetics System of Measles Virus Strain S191", BINGDU XUEBAO - CHINESE JOURNAL OF VIROLOGY, ZHONGGUO WEISHENGWU XUCHUI, BEIJING,, CN, vol. 33, no. 4, 30 June 2017 (2017-06-30), CN , pages 565 - 571, XP055965775, ISSN: 1000-8721, DOI: 10.13242/j.cnki.bingduxuebao.003183
DATABASE NUCLEOTIDE 26 March 2018 (2018-03-26), ANONYMOUS : "Measles virus genotype H1 strain MVs/Zhuhai.CHN/10.17/2[H1], complete genome", XP055965768, retrieved from NCBI Database accession no. MG972194
XU SONG-TAO, JI YI-XIN,ZHU ZHEN,ET AL.: "Hemagglutinin Gene and Amino Acid Characterization Analysis of the H1a Sub-genotype of Wild-type Measles Viruses Circulated in China in 2005", CHINESE JOURNAL OF VACCINES AND IMMUNIZATION, vol. 12, no. 1, 28 December 2006 (2006-12-28), pages 13 - 18, XP055965766, ISSN: 1006-916X
DATABASE NUCLEOTIDE 26 March 2018 (2018-03-26), ANONYMOUS : "Measles virus genotype H1 strain MVs/Zhuhai.CHN/10.17/2[H1], complete genome", XP055965768, retrieved from NCBI Database accession no. MG972194
XU SONG-TAO, JI YI-XIN,ZHU ZHEN,ET AL.: "Hemagglutinin Gene and Amino Acid Characterization Analysis of the H1a Sub-genotype of Wild-type Measles Viruses Circulated in China in 2005", CHINESE JOURNAL OF VACCINES AND IMMUNIZATION, vol. 12, no. 1, 28 December 2006 (2006-12-28), pages 13 - 18, XP055965766, ISSN: 1006-916X
Attorney, Agent or Firm:
XU&PARTNERS, LLC. (CN)
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