Title:
CONSTRUCTION METHOD FOR APPLICABILITY EVALUATION MODEL OF IMMUNE STATE OF T LYMPHOCYTE OF HEPATIC DISEASES OF HEPATITIS B
Document Type and Number:
WIPO Patent Application WO/2019/033444
Kind Code:
A1
Abstract:
Provided are a construction method for an applicability evaluation model of an immune state of T lymphocyte of hepatic diseases of hepatitis B, comprising: (1) detecting T cell activator factors and inhibitory/exhaustion molecules of peripheral blood of a patient by means of a flow cytometry so as to obtain levels of all T cell factors of each detection sample; (2) collecting population statistics, virology, liver function and liver hardness value data of each case and carrying out correlation analysis on clinical indexes and a T cell immunity evaluation index to find the clinical indexes having a close correlation; (3) utilizing the different clinical indexes to establish a plurality of scored ROC curve models, comparing areas under the ROC curve, flexibilities and specificities of different models and selecting the optimal ROC curve; and (4) obtaining different immuno-clinic score equations according to the optimal ROC curve so as to further optimize the optimal immuno-clinic score equation used for evaluating the overall immune state of the T cell.
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Inventors:
HUANG YUEHUA (CN)
ZENG SHOUJIE (CN)
ZENG SHOUJIE (CN)
Application Number:
PCT/CN2017/098402
Publication Date:
February 21, 2019
Filing Date:
August 22, 2017
Export Citation:
Assignee:
HUANG YUEHUA (CN)
PRESEE BIOTECHNOLOGY CO LTD (CN)
PRESEE BIOTECHNOLOGY CO LTD (CN)
International Classes:
G06F19/00
Domestic Patent References:
| WO2006085984A2 | 2006-08-17 |
Foreign References:
| CN106943192A | 2017-07-14 | |||
| CN1444043A | 2003-09-24 | |||
| CN106461639A | 2017-02-22 | |||
| CN106227996A | 2016-12-14 | |||
| CN102024090A | 2011-04-20 |
Other References:
WANG, LIN: "Study on the Correlation of Peripheral T- Cell Immune Function and Chronic HBV", CHINA MASTER'S THESES FULL-TEXT DATABASE, 15 January 2015 (2015-01-15)
ZHOU, FEN ET AL.: "The ROC Analysis on the Diagnostic Value of CD 4+ T Cells in Pulmonary Tuberculosis", CHINESE JOURNAL OF HEALTH LABORATORY TECHNOLOGY, vol. 25, no. 19, 10 October 2015 (2015-10-10), pages 3280 - 3282
ZHOU, FEN ET AL.: "The ROC Analysis on the Diagnostic Value of CD 4+ T Cells in Pulmonary Tuberculosis", CHINESE JOURNAL OF HEALTH LABORATORY TECHNOLOGY, vol. 25, no. 19, 10 October 2015 (2015-10-10), pages 3280 - 3282
Attorney, Agent or Firm:
GUANGZHOU SINO PATENT & TRADEMARK AGENT CO., LTD. (CN)
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