Title:
CONTINUOUS PARTICLE AND MOLECULE SEPARATION WITH AN ANNULAR FLOW CHANNEL
Document Type and Number:
WIPO Patent Application WO2001017662
Kind Code:
A3
Abstract:
The present invention provides apparatuses and methods for continuously separating particles of interest from a heterogenous particle population. the heterogeneity can be based on, for example, magnetic susceptibility, particle size, thermal diffusion, phase solubility, and combinations of the preceding. Based on the heterogeneity, a separation force capable of exploiting the separand (i.e., particles subject to the separation process) is provided. The various embodiments of the present invention preferably employ an annular separation channel, appropriate separation force and flow compartments. In a first embodiment, an annular separation channel having semi-permeable inner and outer cylindrical walls is used to generate lateral convection forces. In a second embodiment of the present invention, an annular separation chanel having heat conductive inner and outer cylindrical walls is used to generate thermal diffusion forces. In a third embodiment, an annular separation channel having non-permeable inner and outer cylindrical walls is used to generate a solubility difference separation force based on solubility coefficient differences between phases of flow compartments. In a fourth embodiment, an annular separation channel having electrically conductive inner and outer cylindrical walls is used to generate an electrophoretic separation force. In a fifth embodiment, an annular separation channel having electrically conductive inner and outer cylindrical walls is used to generate a dielectrophoretic separation force. Yet other embodiments of the present invention provide for the combination of separation forces including lateral convection, thermal diffusion, solubility difference, electrophoretic, dielectrophoretic, and magnetic separation forces.
Inventors:
ZBOROWSKI MACIEJ (US)
CHALMERS JEFF (US)
MOORE LEE R (US)
CHALMERS JEFF (US)
MOORE LEE R (US)
Application Number:
PCT/US2000/024310
Publication Date:
December 06, 2001
Filing Date:
September 01, 2000
Export Citation:
Assignee:
CLEVELAND CLINIC FOUNDATION (US)
UNIV OHIO STATE (US)
ZBOROWSKI MACIEJ (US)
CHALMERS JEFF (US)
MOORE LEE R (US)
UNIV OHIO STATE (US)
ZBOROWSKI MACIEJ (US)
CHALMERS JEFF (US)
MOORE LEE R (US)
International Classes:
B03C5/00; B01D39/16; B01D39/18; B01D49/00; B01D57/00; B01D57/02; B01D61/00; B01D61/14; B03C5/02; G01N27/447; G01N30/00; (IPC1-7): B01D49/00; B01D69/02; B01D63/06; B01D47/00; B03C5/00
Foreign References:
| US5047154A | 1991-09-10 | |||
| US3839201A | 1974-10-01 | |||
| US4976866A | 1990-12-11 | |||
| EP0289858A1 | 1988-11-09 | |||
| GB2319191A | 1998-05-20 | |||
| US5106468A | 1992-04-21 | |||
| DE19860117A1 | 2000-07-13 | |||
| US4454016A | 1984-06-12 |
Other References:
DATABASE WPI Week 199301, Derwent World Patents Index; AN 1993-007930, XP002165930
DATABASE WPI Week 198111, Derwent World Patents Index; AN 1981-C2990D, XP002165931
DATABASE WPI Week 198525, Derwent World Patents Index; AN 1985-012778, XP002165932
DATABASE WPI Week 198111, Derwent World Patents Index; AN 1981-C2990D, XP002165931
DATABASE WPI Week 198525, Derwent World Patents Index; AN 1985-012778, XP002165932
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