Title:
CONTINUOUS PHOTOLYTIC PROCESS FOR THE PREPARATION OF VITAMIN D RELATED SUBSTANCES
Document Type and Number:
WIPO Patent Application WO/2012/033703
Kind Code:
A8
Abstract:
The present application provides a novel method for generation of a vitamin D2 compound using a continuous flow photoisomerization reactor. A compound represented by formula I: [structure] as further defined herein, is mixed with a solvent and a sensitizer, and is then passed through the continuous flow photoisomerization reactor. If X3 and X4 of formula II is tert-butyldimethylsilyl, then formula II is mixed with a deprotection reagent to obtain the vitamin D2 analog.
Inventors:
BAUTA WILLIAM EDWARD (US)
ANDERSON BRUCE GIRARD (US)
CANTRELL JR WILLIAM R (US)
ANDERSON BRUCE GIRARD (US)
CANTRELL JR WILLIAM R (US)
Application Number:
PCT/US2011/050187
Publication Date:
September 20, 2012
Filing Date:
September 01, 2011
Export Citation:
Assignee:
GENZYME CORP (US)
BAUTA WILLIAM EDWARD (US)
ANDERSON BRUCE GIRARD (US)
CANTRELL JR WILLIAM R (US)
BAUTA WILLIAM EDWARD (US)
ANDERSON BRUCE GIRARD (US)
CANTRELL JR WILLIAM R (US)
International Classes:
A01N45/00; A61K31/59
Attorney, Agent or Firm:
PETERSON, Jeffrey D. et al. (100 East Wisconsin Avenue Suite 330, Milwaukee WI, US)
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