Title:
CONTINUOUS PROCESS FOR THE PRODUCTION OF OPTICALLY PURE (S)-beta HYDROXY-gamma-BUTYROLACTONE
Document Type and Number:
WIPO Patent Application WO2004026223
Kind Code:
A3
Abstract:
Disclosed is a continuous process for the production of optically pure (S)-beta-hydroxy-gamma-butyrolactone having constantly maintained optical activity, consisting of hydrogenating 2-50 wt% of a substituted carboxylic acid derivative in a solvent using a fixed bed reactor filled with a precious metal catalyst-impregnated inorganic oxide carrier at 50-500 °C under pressure of 15-5,500 psig at weight-space-velocity of 0.1-10 h<-1>, in which a molar ratio of hydrogen to carboxylic acid derivative ranges from 2 to 10. The desired material can be produced in higher optical purity and at higher yield by the current process which is relatively simpler and environmentally safer than conventional processes. Additionally, increased production efficiency leads to production of the desired material on a large scale.
Inventors:
KWAK BYONG-SUNG (KR)
CHUNG KI-NAM (KR)
KIM TAE-YUN (KR)
KOH KI-HO (KR)
KIM JIN-WOONG (KR)
LEE SANG-IL (KR)
CHUNG KI-NAM (KR)
KIM TAE-YUN (KR)
KOH KI-HO (KR)
KIM JIN-WOONG (KR)
LEE SANG-IL (KR)
Application Number:
PCT/KR2002/001775
Publication Date:
June 09, 2005
Filing Date:
September 18, 2002
Export Citation:
Assignee:
SK CORP (KR)
KWAK BYONG-SUNG (KR)
CHUNG KI-NAM (KR)
KIM TAE-YUN (KR)
KOH KI-HO (KR)
KIM JIN-WOONG (KR)
LEE SANG-IL (KR)
KWAK BYONG-SUNG (KR)
CHUNG KI-NAM (KR)
KIM TAE-YUN (KR)
KOH KI-HO (KR)
KIM JIN-WOONG (KR)
LEE SANG-IL (KR)
International Classes:
C07D307/33; C07B61/00; C07D307/20; C07D307/32; A61K; (IPC1-7): C07D307/32
Domestic Patent References:
| WO2002010147A1 | 2002-02-07 |
Foreign References:
| US6355848B1 | 2002-03-12 | |||
| JPH04266881A | 1992-09-22 | |||
| JPH06172256A | 1994-06-21 |
Other References:
TANAKA A. ET AL: "A novel synthesis of (R)-and (S)-4-hydroxytetrahydrofuran-2-ones", SYNTHESIS, no. 6, 1987, pages 570 - 573, XP001026455
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