Title:
CONTRAST AGENT COMPOSITION FOR DETECTING LESIONAL MARGINS OF ASTROCYTOSIS-RELATED DISEASES COMPRISING QUINOLINE DERIVATIVE AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2021/210962
Kind Code:
A1
Abstract:
The present invention relates to a contrast agent composition for astrocytosis diagnosis, the detection of reactive astrocytes, and image acquisition for brain tumor margins. The present invention presents accurate locations of clustered areas of astrocytes in various diseases accompanied by excessive proliferation or activation of the cells and provides highly reliable information on margins between lesion areas and surrounding normal areas, and thus, particularly, can be effectively used in diagnostic imaging for image-guided surgery such as in surgical resection of brain tumors and the like. Moreover, the present invention indicates not only simply whether the disease is present at the time of examination but also provides the process of change in the margin around the lesion and the extent thereof with high temporal resolution, and thus, based on same, the present invention can be effectively used for early detection of future recurrence or metastasis of tumors and furthermore to evaluate therapeutic responsiveness to specific drugs.
Inventors:
YUN MIJIN (KR)
KIM DONGWOO (KR)
CHANG JONG HEE (KR)
KO HAE YOUNG (KR)
CHUNG JEE-IN (KR)
LEE CHANG JOON (KR)
CHUN HEEJUNG (KR)
KIM DONGWOO (KR)
CHANG JONG HEE (KR)
KO HAE YOUNG (KR)
CHUNG JEE-IN (KR)
LEE CHANG JOON (KR)
CHUN HEEJUNG (KR)
Application Number:
PCT/KR2021/004834
Publication Date:
October 21, 2021
Filing Date:
April 16, 2021
Export Citation:
Assignee:
UNIV YONSEI IACF (KR)
INST BASIC SCIENCE (KR)
INST BASIC SCIENCE (KR)
International Classes:
A61K51/04
Domestic Patent References:
| WO2011119565A1 | 2011-09-29 |
Foreign References:
| KR20160072226A | 2016-06-22 |
Other References:
TAGO TETSURO, TOYOHARA JUN, SENGOKU RENPEI, MURAYAMA SHIGEO, ISHII KENJI: "Monoamine Oxidase B Binding of 18F-THK5351 to Visualize Glioblastoma and Associated Gliosis : An Autopsy-Confirmed Case", CLINICAL NUCLEAR MEDICINE, vol. 44, no. 6, 1 June 2019 (2019-06-01), US , pages 507 - 509, XP055857690, ISSN: 0363-9762, DOI: 10.1097/RLU.0000000000002564
AIKO ISHIKI;RYUICHI HARADA;HIDEAKI KAI;NAOMI SATO;TOMOKO TOTSUNE;NAOKI TOMITA;SHOICHI WATANUKI;KOTARO HIRAOKA;YOICHI ISHIKAWA;YOSH: "Neuroimaging-pathological correlations of [F]THK5351 PET in progressive supranuclear palsy", ACTA NEUROPATHOLOGICA COMMUNICATIONS, vol. 6, no. 1, 29 June 2018 (2018-06-29), London, UK , pages 1 - 10, XP021258011, DOI: 10.1186/s40478-018-0556-7
KIM HEE JIN, CHO HANNA, PARK SEONGBEOM, JANG HYEMIN, RYU YOUNG HOON, CHOI JAE YONG, MOON SEUNG HWAN, OH SEUNG JUN, OH MINYOUNG, NA: "THK5351 and flortaucipir PET with pathological correlation in a Creutzfeldt-Jakob disease patient: a case report", BMC NEUROLOGY, vol. 19, no. 1, 1 December 2019 (2019-12-01), XP055859530, DOI: 10.1186/s12883-019-1434-z
AIKO ISHIKI;RYUICHI HARADA;HIDEAKI KAI;NAOMI SATO;TOMOKO TOTSUNE;NAOKI TOMITA;SHOICHI WATANUKI;KOTARO HIRAOKA;YOICHI ISHIKAWA;YOSH: "Neuroimaging-pathological correlations of [F]THK5351 PET in progressive supranuclear palsy", ACTA NEUROPATHOLOGICA COMMUNICATIONS, vol. 6, no. 1, 29 June 2018 (2018-06-29), London, UK , pages 1 - 10, XP021258011, DOI: 10.1186/s40478-018-0556-7
KIM HEE JIN, CHO HANNA, PARK SEONGBEOM, JANG HYEMIN, RYU YOUNG HOON, CHOI JAE YONG, MOON SEUNG HWAN, OH SEUNG JUN, OH MINYOUNG, NA: "THK5351 and flortaucipir PET with pathological correlation in a Creutzfeldt-Jakob disease patient: a case report", BMC NEUROLOGY, vol. 19, no. 1, 1 December 2019 (2019-12-01), XP055859530, DOI: 10.1186/s12883-019-1434-z
Attorney, Agent or Firm:
PADO IP LAW PLLC (KR)
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