Title:
CONTRAST AGENTS ENCAPSULATING SYSTEMS FOR CEST IMAGING
Document Type and Number:
WIPO Patent Application WO2006032705
Kind Code:
A3
Abstract:
The present invention concerns a contrast agent compound for CEST imaging wherein said contrast agent comprises a proton pool encapsulating system that contains a pool of water mobile shifted protons.
Inventors:
PORT MARC (FR)
Application Number:
PCT/EP2005/054798
Publication Date:
December 21, 2006
Filing Date:
September 23, 2005
Export Citation:
Assignee:
GUERBET SA (FR)
PORT MARC (FR)
PORT MARC (FR)
International Classes:
A61K49/18
Domestic Patent References:
| WO2004023981A2 | 2004-03-25 | |||
| WO1996025955A1 | 1996-08-29 | |||
| WO1990004943A1 | 1990-05-17 | |||
| WO2002043775A2 | 2002-06-06 |
Foreign References:
| US6045821A | 2000-04-04 | |||
| US5534241A | 1996-07-09 | |||
| US6569451B1 | 2003-05-27 | |||
| EP1331012A1 | 2003-07-30 | |||
| EP1466629A1 | 2004-10-13 |
Other References:
HEVERHAGEN J T ET AL: "Encapsulation of gadobutrol in AVE-based liposomal carriers for MR detectability", MAGNETIC RESONANCE IMAGING 2004 UNITED STATES, vol. 22, no. 4, May 2004 (2004-05-01), pages 483 - 487, XP002398083, ISSN: 0730-725X
FOSSHEIM S L ET AL: "Paramagnetic liposomes as MRI contrast agents: influence of liposomal physicochemical properties on the in vitro relaxivity.", MAGNETIC RESONANCE IMAGING. JAN 1999, vol. 17, no. 1, January 1999 (1999-01-01), pages 83 - 89, XP002398084, ISSN: 0730-725X
CARAVAN P ET AL: "GADOLINIUM(III) CHELATES AS MRI CONTRAST AGENTS: STRUCTURE, DYNAMICS, AND APPLICATIONS", CHEMICAL REVIEWS, ACS,WASHINGTON, DC, US, vol. 99, no. 9, September 1999 (1999-09-01), pages 2293 - 2352, XP000852435, ISSN: 0009-2665
AIME SILVIO ET AL: "Highly sensitive MRI chemical exchange saturation transfer agents using liposomes.", ANGEWANDTE CHEMIE (INTERNATIONAL ED. IN ENGLISH) 26 AUG 2005, vol. 44, no. 34, 26 August 2005 (2005-08-26), pages 5513 - 5515, XP002398010, ISSN: 0570-0833
FOSSHEIM S L ET AL: "Paramagnetic liposomes as MRI contrast agents: influence of liposomal physicochemical properties on the in vitro relaxivity.", MAGNETIC RESONANCE IMAGING. JAN 1999, vol. 17, no. 1, January 1999 (1999-01-01), pages 83 - 89, XP002398084, ISSN: 0730-725X
CARAVAN P ET AL: "GADOLINIUM(III) CHELATES AS MRI CONTRAST AGENTS: STRUCTURE, DYNAMICS, AND APPLICATIONS", CHEMICAL REVIEWS, ACS,WASHINGTON, DC, US, vol. 99, no. 9, September 1999 (1999-09-01), pages 2293 - 2352, XP000852435, ISSN: 0009-2665
AIME SILVIO ET AL: "Highly sensitive MRI chemical exchange saturation transfer agents using liposomes.", ANGEWANDTE CHEMIE (INTERNATIONAL ED. IN ENGLISH) 26 AUG 2005, vol. 44, no. 34, 26 August 2005 (2005-08-26), pages 5513 - 5515, XP002398010, ISSN: 0570-0833
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