Title:
CONTRAST COMPOUND, CONTRAST MEDIUM FOR MRI, AND METHOD FOR MRI
Document Type and Number:
WIPO Patent Application WO/1998/023293
Kind Code:
A1
Abstract:
A compound comprising an MRI contrast compound and a sugar chain polymer bonded thereto, especially hyaluronic acid, corresponding to a glycoprotein receptor specifically manifesting in a tumor or organ; an MRI contrast medium containing the compound; and a method for imaging a tumor and/or a liver with the MRI contrast medium. An MRI contrast compound and an MRI contrast medium both having a target site directivity are obtained by modifying an MRI contrast compound with a sugar chain polymer corresponding to a glycoprotein receptor specifically manifesting in a tumor or organ. In particular, selection of hyaluronic acid, which is highly hydrophilic, as the modifying sugar chain polymer is expected to be especially effective in avoiding the phagocytosis by RES. Since target sites can be imaged specifically, the contrast medium enables diagnosis in a small dose, i.e., toxicity can be reduced.
Inventors:
AKAIKE TOSHIHIRO (JP)
MIKAWA MASATO (JP)
MARUYAMA ATSUSHI (JP)
TAKAHASHI MASAYA (US)
MIYAZAWA TOMOAKI (JP)
MIWA NAOTO (JP)
MIKAWA MASATO (JP)
MARUYAMA ATSUSHI (JP)
TAKAHASHI MASAYA (US)
MIYAZAWA TOMOAKI (JP)
MIWA NAOTO (JP)
Application Number:
PCT/JP1997/004343
Publication Date:
June 04, 1998
Filing Date:
November 27, 1997
Export Citation:
Assignee:
NIHON SCHERING K K (JP)
AKAIKE TOSHIHIRO (JP)
MIKAWA MASATO (JP)
MARUYAMA ATSUSHI (JP)
TAKAHASHI MASAYA (US)
MIYAZAWA TOMOAKI (JP)
MIWA NAOTO (JP)
AKAIKE TOSHIHIRO (JP)
MIKAWA MASATO (JP)
MARUYAMA ATSUSHI (JP)
TAKAHASHI MASAYA (US)
MIYAZAWA TOMOAKI (JP)
MIWA NAOTO (JP)
International Classes:
A61K49/12; A61K49/18; (IPC1-7): A61K47/48; A61K49/00
Foreign References:
| JPH0812596A | 1996-01-16 | |||
| JP4502456A |
Attorney, Agent or Firm:
Takashima, Hajime (3-9 Hiranomachi 3-chome, Chuo-k, Osaka-shi Osaka 541, JP)
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