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Title:
CONTROL OF BIOFILM DISPERSAL FOR THE PRODUCTION OF AMINO ACIDS OR AMINO ACID-DERIVED PRODUCTS
Document Type and Number:
WIPO Patent Application WO/2018/032240
Kind Code:
A1
Abstract:
Provided herein is a genetically modified host cell comprising a heterologous nucleic acid encoding a biofilm dispersal polypeptide that decreases intracellular c-di-GMP levels and enhances the production of lysine and lysine derivatives. Further provided are methods of generating such cell and producing lysine and lysine derivatives using the genetically modified host cell.

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Inventors:
CHOU HOWARD (CN)
LIU XIUCAI (CN)
Application Number:
PCT/CN2016/095281
Publication Date:
February 22, 2018
Filing Date:
August 15, 2016
Export Citation:
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Assignee:
CATHAY R&D CENTER CO LTD (CN)
CATHAY IND BIOTECH LTD (GB)
International Classes:
C12P13/08; C12N1/21; C12N5/10; C12N15/52; C12N15/70; C12N15/74; C12R1/15
Domestic Patent References:
WO2016054792A12016-04-14
WO2015109265A12015-07-23
Foreign References:
CN101240258A2008-08-13
CN105624175A2016-06-01
Other References:
MA, Q. ET AL.: "Engineering a novel c-di-GMP-binding protein for biofilm dispersal", ENVIRONMENTAL MICROBIOLOGY, vol. 13, no. 3, 31 December 2011 (2011-12-31), pages 631 - 642, XP055381674
MA, Q. ET AL.: "Escherichia coli BdcA controls biofilm dispersal in Pseudomonas aeruginosa and Rhizobium meliloti", BMC RESEARCH NOTES, vol. 4, 26 October 2011 (2011-10-26), XP021114676
See also references of EP 3497226A4
Attorney, Agent or Firm:
NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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