CONTROL OF GLYCOFORMS IN IGG - SMITHKLINE BEECHAM CORP

Title:

CONTROL OF GLYCOFORMS IN IGG

Document Type and Number:

WIPO Patent Application WO2002076578

Kind Code:

A9

Abstract:

The present invention provides a method to control the level of non-glycosylated heavy chain variant of an IgG in a CHO cell culture process by adjusting temperature and batched medium osmolality.

Inventors:

DEVRIES RUTH L (US)
VICKROY THOMAS B (US)

Application Number:

PCT/US2002/009998

Publication Date:

March 06, 2003

Filing Date:

March 27, 2002

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Assignee:

SMITHKLINE BEECHAM CORP (US)
DEVRIES RUTH L (US)
VICKROY THOMAS B (US)

International Classes:

C12P21/08; C07K16/00; C12N5/07; C12N5/078; C12P21/04; (IPC1-7): C12P39/00; C12P21/04

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