Title:
CONTROL OF PLASTID ASSOCIATED PROTEIN DEGRADATION II
Document Type and Number:
WIPO Patent Application WO/2019/171080
Kind Code:
A3
Abstract:
SP1, SP2 CDC48 and PUX10 exist at the core of a system for chloroplast protein removal, designated Chloroplast-Associated Protein Degradation (CHLORAD). This system targets chloroplast substrates for degradation, either as a homeostatic, quality-control process for the removal damaged proteins under stress, or as a regulatory mechanism to control plastid development and functions. Plants are genetically modified so as to alter their expression levels of SP2 and/or SP1 and/or PUX10 and thereby modify plastid development during growth and development of the plant. Such modified plants show beneficial or desirable alterations in their chloroplasts during growth and development and provide for control of leaf chlorophyll amounts and senescence.
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Inventors:
JARVIS PAUL (GB)
Application Number:
PCT/GB2019/050658
Publication Date:
December 26, 2019
Filing Date:
March 08, 2019
Export Citation:
Assignee:
UNIV OXFORD INNOVATION LTD (GB)
International Classes:
C12N15/82; A01H5/00; C07K14/415; C12N15/29
Domestic Patent References:
| WO2014024440A1 | 2014-02-13 | |||
| WO2014037735A1 | 2014-03-13 |
Foreign References:
| EP1033405A2 | 2000-09-06 | |||
| US20080184386A1 | 2008-07-31 |
Other References:
DATABASE TAIR [online] 16 January 2013 (2013-01-16), "Germplasm: SAIL_1187_B06", XP002795139, retrieved from Phoenix Bioinformatics Database accession no. SAIL_1187_B06
DATABASE TAIR [online] 22 October 2007 (2007-10-22), "Polymorphism: pux10-1", XP002795140, retrieved from Phoenix Bioinformatics
DATABASE TAIR [online] 19 February 2015 (2015-02-19), "Germplasm: SALK_139056", XP002795141, retrieved from Phoenix Bioinformatics Database accession no. SALK_139056
DATABASE TAIR [online] 18 February 2015 (2015-02-18), "Polymorphism: SALKseq_139056.0", XP002795142, retrieved from Phoenix Bioinformatics Database accession no. SALKseq_139056.0
DATABASE TAIR [online] 22 October 2017 (2017-10-22), "Polymorphism: SALK_139056.54.25.x", XP002795143, retrieved from Phoenix Bioinformatics Database accession no. SALK_139056.54.25.x
DATABASE UniProt [online] 1 April 2015 (2015-04-01), "RecName: Full=Plant UBX domain-containing protein 10 {ECO:0000303|Ref.4}; Short=PUX10 {ECO:0000303|Ref.4};", XP002795144, retrieved from EBI accession no. UNIPROT:Q9M0N1 Database accession no. Q9M0N1
DATABASE EMBL [online] 24 September 1998 (1998-09-24), "Arabidopsis thaliana BAC T12H20.", XP002795145, retrieved from EBI Database accession no. AF080119
DATABASE EMBL [online] 16 March 2000 (2000-03-16), "Arabidopsis thaliana DNA chromosome 4, contig fragment No. 30", XP002795146, retrieved from EBI Database accession no. AL161518
DATABASE Genbank Nucleotide [online] 20 March 2017 (2017-03-20), "Arabidopsis thaliana UBX domain-containing protein (AT4G10790), mRNA; NCBI Reference Sequence: NM_117147.4", XP002795147, retrieved from NCBI Database accession no. NM_117147
DATABASE EMBL [online] 9 September 2004 (2004-09-09), "Arabidopsis thaliana mRNA for predicted protein of unknown function, partial cds, clone: RAFL25-22-H05.", XP002795148, retrieved from EBI Database accession no. AK176682
DATABASE ENA [online] 13 May 2011 (2011-05-13), "Arabidopsis thaliana (thale cress) UBX domain-containing protein", XP002795149, retrieved from EBI accession no. EMBL: Database accession no. AEE82929
FRANZISKA K. KRETZSCHMAR ET AL: "PUX10 Is a Lipid Droplet-Localized Scaffold Protein That Interacts with CELL DIVISION CYCLE48 and Is Involved in the Degradation of Lipid Droplet Proteins", THE PLANT CELL, vol. 30, no. 9, 7 August 2018 (2018-08-07), US, pages 2137 - 2160, XP055629990, ISSN: 1040-4651, DOI: 10.1105/tpc.18.00276
DATABASE TAIR [online] 22 October 2007 (2007-10-22), "Polymorphism: pux10-1", XP002795140, retrieved from Phoenix Bioinformatics
DATABASE TAIR [online] 19 February 2015 (2015-02-19), "Germplasm: SALK_139056", XP002795141, retrieved from Phoenix Bioinformatics Database accession no. SALK_139056
DATABASE TAIR [online] 18 February 2015 (2015-02-18), "Polymorphism: SALKseq_139056.0", XP002795142, retrieved from Phoenix Bioinformatics Database accession no. SALKseq_139056.0
DATABASE TAIR [online] 22 October 2017 (2017-10-22), "Polymorphism: SALK_139056.54.25.x", XP002795143, retrieved from Phoenix Bioinformatics Database accession no. SALK_139056.54.25.x
DATABASE UniProt [online] 1 April 2015 (2015-04-01), "RecName: Full=Plant UBX domain-containing protein 10 {ECO:0000303|Ref.4}; Short=PUX10 {ECO:0000303|Ref.4};", XP002795144, retrieved from EBI accession no. UNIPROT:Q9M0N1 Database accession no. Q9M0N1
DATABASE EMBL [online] 24 September 1998 (1998-09-24), "Arabidopsis thaliana BAC T12H20.", XP002795145, retrieved from EBI Database accession no. AF080119
DATABASE EMBL [online] 16 March 2000 (2000-03-16), "Arabidopsis thaliana DNA chromosome 4, contig fragment No. 30", XP002795146, retrieved from EBI Database accession no. AL161518
DATABASE Genbank Nucleotide [online] 20 March 2017 (2017-03-20), "Arabidopsis thaliana UBX domain-containing protein (AT4G10790), mRNA; NCBI Reference Sequence: NM_117147.4", XP002795147, retrieved from NCBI Database accession no. NM_117147
DATABASE EMBL [online] 9 September 2004 (2004-09-09), "Arabidopsis thaliana mRNA for predicted protein of unknown function, partial cds, clone: RAFL25-22-H05.", XP002795148, retrieved from EBI Database accession no. AK176682
DATABASE ENA [online] 13 May 2011 (2011-05-13), "Arabidopsis thaliana (thale cress) UBX domain-containing protein", XP002795149, retrieved from EBI accession no. EMBL: Database accession no. AEE82929
FRANZISKA K. KRETZSCHMAR ET AL: "PUX10 Is a Lipid Droplet-Localized Scaffold Protein That Interacts with CELL DIVISION CYCLE48 and Is Involved in the Degradation of Lipid Droplet Proteins", THE PLANT CELL, vol. 30, no. 9, 7 August 2018 (2018-08-07), US, pages 2137 - 2160, XP055629990, ISSN: 1040-4651, DOI: 10.1105/tpc.18.00276
Attorney, Agent or Firm:
HGF LIMITED (GB)
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