Title:
A CONTROLLED DRUG RELEASE SYSTEM OF PHOTORESPONSIVE NANOCARRIERS, METHODS OF MAKING AND USING THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/213089
Kind Code:
A1
Abstract:
Disclosed herein is a controlled drug release system of photoresponsive nanocarriers. Also provided are methods of making the nanocarriers. Also provided are method of using the nanocarriers for the treatment of diseases.
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Inventors:
WANG WEIPING (CN)
LONG KAIQI (CN)
LONG KAIQI (CN)
Application Number:
PCT/CN2021/081262
Publication Date:
October 28, 2021
Filing Date:
March 17, 2021
Export Citation:
Assignee:
UNIV HONG KONG (CN)
International Classes:
A61K31/37; A61K9/00; A61P35/00; C08G69/00
Domestic Patent References:
| WO2011130114A1 | 2011-10-20 |
Other References:
LONG KAIQI, LIU YUWEI, LI YAFEI, WANG WEIPING: "Self-assembly of trigonal building blocks into nanostructures: molecular design and biomedical applications.", JOURNAL OF MATERIALS CHEMISTRY B, vol. 8, no. 31, 12 August 2020 (2020-08-12), GB, pages 6739 - 6752, XP055860879, ISSN: 2050-750X, DOI: 10.1039/D0TB01128B
WANG WEIPING, CHAU YING: "Self-assembly mediated platform for rapid and facile preparation of peptide-functionalized nanoparticles with high stability.", CHEMISTRY OF MATERIALS, vol. 24, no. 5, 13 March 2012 (2012-03-13), US, pages 946 - 953, XP055860884, ISSN: 0897-4756, DOI: 10.1021/cm202860h
WANG WEIPING, CHAU YING: "Efficient and facile formation of two-component nanoparticles via aromatic moiety directed self-assembly.", CHEMICAL COMMUNICATIONS, vol. 47, no. 37, 26 April 2011 (2011-04-26), UK, pages 10224 - 10226, XP055860886, ISSN: 1359-7345, DOI: 10.1039/c1cc11048a
REHM THOMAS H., GRÖHN FRANZISKA, SCHMUCK CARSTEN: "Self-assembly of a triple-zwitterion in polar solutions: hierarchical formation of nanostructures.", SOFT MATTER, vol. 8, no. 11, 7 February 2012 (2012-02-07), GB, pages 3154 - 3162, XP055860890, ISSN: 1744-683X, DOI: 10.1039/c2sm07153c
JIN YUE, SONG LIANG, WANG DALI, QIU FENG, YAN DEYUE, ZHU BANGSHANG, ZHU XINYUAN: "Synthesis and self-assembly of nonamphiphilic hyperbranched polyoximes.", SOFT MATTER, vol. 8, no. 39, 24 July 2012 (2012-07-24), GB, pages 10017 - 10025, XP055860893, ISSN: 1744-683X, DOI: 10.1039/c2sm26124c
GANDIOSO ALBERT, CANO MARC, MASSAGUER ANNA, MARCHÁN VICENTE: "A Green Light-Triggerable RGD Peptide for Photocontrolled Targeted Drug Delivery: Synthesis and Photolysis Studies", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 81, no. 23, 9 November 2016 (2016-11-09), pages 11556 - 11564, XP055860899, ISSN: 0022-3263, DOI: 10.1021/acs.joc.6b02415
ZHANG YAJIE, LI XIAO, WU TIANTIAN, SUN JIAN, WANG XUEWEI, CAO LEILEI, FENG FUDE: "Cationic polythiophenes as gene delivery enhancer.", ACS APPLIED MATERIALS & INTERFACES., vol. 9, no. 20, 11 May 2017 (2017-05-11), US, pages 16735 - 16740, XP055860900, ISSN: 1944-8244, DOI: 10.1021/acsami.7b01987
YAMAZOE SAYUMI, LIU QINGYANG, MCQUADE LINDSEY E., DEITERS ALEXANDER, CHEN JAMES K.: "Sequential gene silencing using wavelength‐selective caged morpholino oligonucleotides.", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 53, no. 38, 15 September 2014 (2014-09-15), pages 10114 - 10118, XP055860905, ISSN: 1433-7851, DOI: 10.1002/anie.201405355
FOURNIER LUDOVIC, AUJARD ISABELLE, LE SAUX THOMAS, MAURIN SYLVIE, BEAUPIERRE SANDRA, BAUDIN JEAN‐BERNARD, JULLIEN LUDOVIC: "Coumarinylmethyl caging groups with redshifted absorption", CHEMISTRY - A EUROPEAN JOURNAL, vol. 19, no. 51, 16 December 2013 (2013-12-16), pages 17494 - 17507, XP055860906, ISSN: 0947-6539, DOI: 10.1002/chem.201302630
GANDIOSO ALBERT, PALAU MARTA, NIN-HILL ALBA, MELNYK IVANNA, ROVIRA CARME, NONELL SANTI, VELASCO DOLORES, GARCÍA-AMORÓS JAUME, MARC: "Sequential uncaging with green light can be achieved by fine‐tuning the structure of a dicyanocoumarin chromophore.", CHEMISTRY OPEN, vol. 6, no. 3, 1 June 2017 (2017-06-01), pages 375 - 384, XP055860909, ISSN: 2191-1363, DOI: 10.1002/open.201700067
WANG WEIPING, CHAU YING: "Self-assembly mediated platform for rapid and facile preparation of peptide-functionalized nanoparticles with high stability.", CHEMISTRY OF MATERIALS, vol. 24, no. 5, 13 March 2012 (2012-03-13), US, pages 946 - 953, XP055860884, ISSN: 0897-4756, DOI: 10.1021/cm202860h
WANG WEIPING, CHAU YING: "Efficient and facile formation of two-component nanoparticles via aromatic moiety directed self-assembly.", CHEMICAL COMMUNICATIONS, vol. 47, no. 37, 26 April 2011 (2011-04-26), UK, pages 10224 - 10226, XP055860886, ISSN: 1359-7345, DOI: 10.1039/c1cc11048a
REHM THOMAS H., GRÖHN FRANZISKA, SCHMUCK CARSTEN: "Self-assembly of a triple-zwitterion in polar solutions: hierarchical formation of nanostructures.", SOFT MATTER, vol. 8, no. 11, 7 February 2012 (2012-02-07), GB, pages 3154 - 3162, XP055860890, ISSN: 1744-683X, DOI: 10.1039/c2sm07153c
JIN YUE, SONG LIANG, WANG DALI, QIU FENG, YAN DEYUE, ZHU BANGSHANG, ZHU XINYUAN: "Synthesis and self-assembly of nonamphiphilic hyperbranched polyoximes.", SOFT MATTER, vol. 8, no. 39, 24 July 2012 (2012-07-24), GB, pages 10017 - 10025, XP055860893, ISSN: 1744-683X, DOI: 10.1039/c2sm26124c
GANDIOSO ALBERT, CANO MARC, MASSAGUER ANNA, MARCHÁN VICENTE: "A Green Light-Triggerable RGD Peptide for Photocontrolled Targeted Drug Delivery: Synthesis and Photolysis Studies", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 81, no. 23, 9 November 2016 (2016-11-09), pages 11556 - 11564, XP055860899, ISSN: 0022-3263, DOI: 10.1021/acs.joc.6b02415
ZHANG YAJIE, LI XIAO, WU TIANTIAN, SUN JIAN, WANG XUEWEI, CAO LEILEI, FENG FUDE: "Cationic polythiophenes as gene delivery enhancer.", ACS APPLIED MATERIALS & INTERFACES., vol. 9, no. 20, 11 May 2017 (2017-05-11), US, pages 16735 - 16740, XP055860900, ISSN: 1944-8244, DOI: 10.1021/acsami.7b01987
YAMAZOE SAYUMI, LIU QINGYANG, MCQUADE LINDSEY E., DEITERS ALEXANDER, CHEN JAMES K.: "Sequential gene silencing using wavelength‐selective caged morpholino oligonucleotides.", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 53, no. 38, 15 September 2014 (2014-09-15), pages 10114 - 10118, XP055860905, ISSN: 1433-7851, DOI: 10.1002/anie.201405355
FOURNIER LUDOVIC, AUJARD ISABELLE, LE SAUX THOMAS, MAURIN SYLVIE, BEAUPIERRE SANDRA, BAUDIN JEAN‐BERNARD, JULLIEN LUDOVIC: "Coumarinylmethyl caging groups with redshifted absorption", CHEMISTRY - A EUROPEAN JOURNAL, vol. 19, no. 51, 16 December 2013 (2013-12-16), pages 17494 - 17507, XP055860906, ISSN: 0947-6539, DOI: 10.1002/chem.201302630
GANDIOSO ALBERT, PALAU MARTA, NIN-HILL ALBA, MELNYK IVANNA, ROVIRA CARME, NONELL SANTI, VELASCO DOLORES, GARCÍA-AMORÓS JAUME, MARC: "Sequential uncaging with green light can be achieved by fine‐tuning the structure of a dicyanocoumarin chromophore.", CHEMISTRY OPEN, vol. 6, no. 3, 1 June 2017 (2017-06-01), pages 375 - 384, XP055860909, ISSN: 2191-1363, DOI: 10.1002/open.201700067
Attorney, Agent or Firm:
LIU, SHEN & ASSOCIATES (CN)
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