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Title:
CONTROLLED RELEASE DELIVERY OF PEPTIDE OR PROTEIN
Document Type and Number:
WIPO Patent Application WO1999038495
Kind Code:
A3
Abstract:
Compositions and devices for the controlled release delivery of a peptide or protein drug are produced by dispersing a glassy matrix phase comprising the peptide or protein drug and a thermoprotectant in a bioerodable, biocompatible polymer at a temperature that is below the glass transition temperature of the glassy matrix phase and above the melting point of the polymer. The method and composition of the invention may be employed for the local delivery of angiogenic amounts of basic fibroblast growth factor or vascular endothelial growth factor.

Inventors:
WANG YU-CHANG JOHN (US)
YANG BING (US)
JENNINGS ROBERT N JR (US)
PROTTER ANDREW A (US)
Application Number:
PCT/US1999/001967
Publication Date:
September 30, 1999
Filing Date:
January 28, 1999
Export Citation:
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Assignee:
SCIOS INC (US)
WANG YU CHANG JOHN (US)
YANG BING (US)
JENNINGS ROBERT N JR (US)
PROTTER ANDREW A (US)
International Classes:
A61K9/00; A61K9/16; A61K38/00; A61K47/26; A61K47/34; A61P17/02; A61K9/20; (IPC1-7): A61K9/16; A61K9/00
Domestic Patent References:
WO1991016881A11991-11-14
WO1994005257A11994-03-17
WO1993010758A11993-06-10
WO1990013780A11990-11-15
WO1998043611A11998-10-08
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