Persons afflicted by diabetes mellitus ("diabetes") are unable to secrete sufficient insulin, which results in excess of sugar in the bloodstream. Sufferers from diabetes may require treatment consisting of hypodermic injections of insulin, as the latter assists the body to metabolise the excess sugar. It is often necessary to store insulin ready for use by injection or the like.

In order to maintain an insulin preparation in a fresh condition, it should be kept at a temperature lower than normal ambient temperature. This requires that the insulin should be stored in a refrigerator or other cooling device, such as, for example, an ice box. However, people suffering from diabetes who require several injections of insulin per day are inconvenienced if they are away from home for a long period of time.

W083/04089 discloses a portable carrying pouch which contains a removable refrigerating agent, for use when storing insulin. Other portable carrying devices are known for purposes, other than storage of medicines, for example, for carrying food.

By way of example, US patent 4211091 discloses a pliable, insulated bag for use as a lunch bag for temporary storage of foodstuffs; US patent 4530220 discloses a deformable bag for use as a cooling medium, which bag comprises an envelope filled with a gel substance, the whole bag being intended to be cooled to a temperature less than -100C.

Japanese patent application 6178792A discloses a medical insulating appliance having high cooling, anti-flammatory and disinfecting effects. Such an appliance is typically used after cooling in a refrigerator. However, such an appliance is designed for cooling a body part and not for transporting and/or cooling medicament.

It is therefore an aim of the present invention to provide a portable cooling pouch which does not require refrigeration and does not contain removable refrigeration parts.

According to the present invention, there is provided a portable pouch for cooling and storing vials and the like, said pouch comprising: (a) a first web member of water permeable material; (b) a second web member of water permeable material; (c) hinge means connecting an edge of said first web member, directly or indirectly, to said second web member; (d) fastening means for fastening remaining edges of said first web member to remaining edges of said second web member, wherein at least one of said web members includes a plurality of compartments each containing water absorbent granular material and said hinge means is free of such compartments.

Typically, each of the web members comprises a plurality of such compartments, each of which contains such a water absorbent granular material.

Preferably each of the web members is of quadrilateral shape, such as rectangular. The web members are preferably integrally formed from a single web, arranged to be folded along the hinge.

The fastening means typically comprise at least one first element comprising a multiplicity of hooks, and at least one complementary second element comprising a multiplicity of loops engageable with the hooks on the first element. Both the first and second elements are typically in the form of strip or tape.

Preferably, the web members are arranged to be fastened together by the fastening means in such a way that one web member extends beyond the free edge of the other of the web members, so as to form a flap foldable over a marginal portion of the other web member.

Such a flap preferably has fastening means on a first face of the one web member for engagement with complementary fastening means on the marginal portion on the other web member.

According to a first embodiment of the invention, the hinge means connect an edge of the first web member directly to the second web member.

According to a second embodiment of the invention, the hinge means connect an edge of the first web indirectly to the second web member.

In the second embodiment, there is preferably an intervening panel connecting the hinge means to the second web member. In this embodiment, the pouch can, in some arrangements, take the form of a substantially closed box, in which the first web member provides a closure for a tray constituted by the second web, the above-mentioned panel and a plurality of edge panels. However, it is envisaged in this embodiment that the first web member, the second web member, the intervening panel and the edge panels can be formed from a single web.

Preferably, the water permeable material comprises a durable, flexible textile material, such as a woven fabric. A particularly preferred textile material comprises a polyester/cotton fabric blend, although other textile materials such as a nylon or an acrylic may also be used.

Typically, the water absorbent material is one which is capable of regeneration after it has been dried out, preferably over repeated water absorption and desorption cycles.

The water absorbent material preferably comprises a polymeric material, such as an acrylic polymer. Such a polymer may be a cross-linked acrylate or methacrylate polymer, such a sodium salt thereof.

It is particularly preferred that the granular material is one which has a transition between respective hydrated forms at or close to ambient temperature, such that the latent heat absorbed or evolved on passage through the transition temperature helps to maintain the temperature substantially constant for a prolonged period.

The compartments containing the water-absorbent material may be formed by sewing an elongate double skinned web member in sewing lines extending along the length of the web member; a plurality of such sewing lines is preferably employed so as to divide the web members lengthwise into a plurality of the compartments.

At least one further sewing line is preferably provided transverse to the sewing lines mentioned above so as to control the distribution of the water absorbent material along the length of the respective compartment or compartments. It is preferred that the further sewing line is provided along the hinge means.

Preferably, the pouch is flexible.

The present invention further comprises a method of storing a medicine (preferably a vial or the like) which comprises treating the web members of a pouch according to the invention with cold water, either before or after shaping the web members to form the pouch, so as to cause swelling of the water absorbent material within the compartments thereof, and disposing the medicine within the pouch while the compartments contain the swollen water absorbent material.

The invention will now be described, by way of example only, with reference to the accompanying drawings, in which: Figure 1 is a plan view of a pouch according to the first embodiment of the invention; Figure 2 is a cross-section along the line AA shown in Figure 1; and Figure 3 is a plan view of a pouch according to the second embodiment of the invention.

Referring to the drawings, a fabric web 1 comprises a double skinned front fabric panel 2 and a corresponding double- skinned rear fabric panel 3. The front panel 2 has a series of parallel, longitudinally extending stitching lines 11, which (with the corresponding edges of the respective panel) form respective compartments 4a, 4b and 4c, each of which contains water absorbent grains 5 of sodium polyacrylate (see Figure 2).

The rear panel 3 also has a series of parallel, longitudinally extending stitching lines 12, which (with the corresponding edges of the respective panel) form respective compartments 6a, 6b and 6c. A strip 7a of one part of a hook- and-loop type fastener of the type commercially available under the trade mark Velcro is sewn to a side edge of the front panel 2; a complementary part of the fastener 9a is sewn to a side edge of the rear panel 3.

A further strip 7b of one part of such a hook-and-loop type fastener is sewn to the opposed side edge of the front panel 2; a complementary part of the fastener 9b is sewn to the corresponding side edge of rear panel 3.

A further strip 10 of one part of such a hook-and-loop type fastener is sewn to the free end of the front panel 2; a complementary part of the fastener (not shown) is sewn to a corresponding end of rear panel 3 (on the obverse face thereof).

The free end of the front panel 2 to which strip 10 is sewn thereby forms a flap, which can overlap the corresponding free end of rear panel 3.

A foldline 8 is provided between the front panel 2 and the rear panel 3. This foldline is preferably defined by a row of stitching which separates compartment 4a from 6a, compartment 4b from 6b, compartment 4c from 6c, and compartment 4d from 6d.

The front and rear panels 2,3 are folded together about the foldline and secured together by the various fastening means to form a pouch.

The whole web may be immersed in cold water, typically for about 90 seconds; the grains 5 then form a gel-like substance which can retain the temperature of the water for approximately 3 to 4 days. If a temperature lower than that of the cold water is required, it is possible to place the whole web in a refrigerator, or the like, in order to lower the temperature.

Once the web is at the desired temperature, it is folded along the foldline 8, in order that the front panel 2 can be fastened to the rear panel 3 by means of the fastener 7a,7b, 9a,9b so as to form a pouch. Insulin or other medication that needs to be stored at a lower temperature than room temperature, can then be stored in the pouch, typically in vials or the like, for a period of typically 3 to 4 days.

Referring to Figure 3, a fabric webbed box-like pouch 31 comprises a double skinned bottom fabric panel 32 and a corresponding double skinned top fabric panel 33. The bottom panel 32 is attached to the top panel 33 indirectly by hinge panel 34. Hinge panel 34 is attached to the bottom panel 32 along stitching line 35; hinge panel 34 is also attached to the top panel 33 along stitching line 36.

Three further upstanding wall panels 37, 38 and 39 are attached to the bottom panel 32 along respective stitching lines 40, 41 and 42 to form a box-like structure. The top panel 33 can be attached to the upstanding wall panels 37, 38 and 39 by zip fastening 43.

The bottom panel 32 has a series of parallel, longitudinally extending stitching lines 44, which (with the corresponding edges of the respective panel) form respective compartments 45a, 45b and 45c, each of which contains water- absorbent grains 5 of sodium polyacrylate (corresponding to those described above with reference to Figure 2).

The top panel 33 also has a series of parallel, longitudinally extending stitching lines 46, which (with the corresponding edges of the respective panel) form respective compartments 47a, 47b and 47c.

The whole pouch may be immersed in cold water, typically for about 90 seconds; the grains 5 then form a gel-like substance which can retain the temperature of the water for approximately 3 to 4 days. If a temperature lower than that of the cold water is required, it is possible to place the whole web in a refrigerator, or the like, in order to lower the temperature.

Example Measurements were made of the temperature of the inside of an empty pouch made according to the present invention.

After immersion of the pouch in cold water, temperature measurements were made of the pouch which was suspended in an incubator where air temperature was maintained close to 37.80C (100"F) with low relative humidity (15%). Measurements were made at 10 minute intervals for periods of between 24 and 48 hours.

The pouch maintained internal temperatures below 30"C for periods exceeding 14 hours.