Title:
COORDINATION POLYMER NANO MATERIAL HAVING COMBINED PHOTODYNAMIC-STARVATION THERAPY FUNCTION, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/130514
Kind Code:
A1
Abstract:
A coordination polymer nano material having a combined photodynamic-starvation therapy function, a preparation method therefor and an application thereof. The coordination polymer nano material comprises a carrier and an enzyme. The enzyme is loaded in the carrier. The enzyme is glucose oxidase (GOx) or a mimic enzyme having a GOx-like activity. The carrier is a 1,2,4-triazole copper (I) complex. The GOx in the coordination polymer nano material can be specifically released in a tumor cell, and catalyze the oxidation of glucose in the tumor cell, consuming glucose and oxygen in the tumor cell, and improving the levels of acidity, low oxygen and hydrogen peroxide, thereby blocking the energy supply to the tumor cell, and achieving a starvation therapy. Meanwhile, hydrogen peroxide produced by the starvation therapy can also be used as a raw material for a photodynamic reaction of the 1,2,4-triazole copper (I) complex, thereby enhancing the type I photodynamic therapy effect, and finally achieving an efficient combined photodynamic-starvation therapy.
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Inventors:
PAN YIHANG (CN)
XU YUZHI (CN)
ZENG LELI (CN)
XU YUZHI (CN)
ZENG LELI (CN)
Application Number:
PCT/CN2022/073661
Publication Date:
July 13, 2023
Filing Date:
January 25, 2022
Export Citation:
Assignee:
THE SEVENTH AFFILIATED HOSPITAL SUN YAT SEN UNIV (CN)
International Classes:
A61K41/00; A61K9/51; A61K38/44; A61P35/00; B82Y5/00; B82Y40/00
Foreign References:
| CN109030802A | 2018-12-18 | |||
| CN109078176A | 2018-12-25 | |||
| CN111253581A | 2020-06-09 | |||
| CN111450270A | 2020-07-28 |
Other References:
ZENG LELI, HUANG KAI, WAN YILIN, ZHANG JING, YAO XIKUANG, JIANG CHAO, LIN JING, HUANG PENG: "Programmable starving-photodynamic synergistic cancer therapy", SCIENCE CHINA MATERIALS, vol. 63, no. 4, 1 April 2020 (2020-04-01), pages 611 - 619, XP093077056, ISSN: 2095-8226, DOI: 10.1007/s40843-019-1226-8
LIU SI‐YANG, XU YUZHI, YANG HUIHUI, LIU LIPING, ZHAO MEITING, YIN WEN, XU YAN‐TONG, HUANG YING, TAN CHAOLIANG, DAI ZONG, ZHANG HUA: "Ultrathin 2D Copper(I) 1,2,4‐Triazolate Coordination Polymer Nanosheets for Efficient and Selective Gene Silencing and Photodynamic Therapy", ADVANCED MATERIALS, VCH PUBLISHERS, DE, vol. 33, no. 18, 1 May 2021 (2021-05-01), DE , XP093077060, ISSN: 0935-9648, DOI: 10.1002/adma.202100849
ZHANG JIE-PENG, LIN YAN-YONG, HUANG XIAO-CHUN, CHEN XIAO-MING: "Copper(I) 1,2,4-Triazolates and Related Complexes: Studies of the Solvothermal Ligand Reactions, Network Topologies, and Photoluminescence Properties", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, vol. 127, no. 15, 1 April 2005 (2005-04-01), pages 5495 - 5506, XP093077064, ISSN: 0002-7863, DOI: 10.1021/ja042222t
LIU SI‐YANG, XU YUZHI, YANG HUIHUI, LIU LIPING, ZHAO MEITING, YIN WEN, XU YAN‐TONG, HUANG YING, TAN CHAOLIANG, DAI ZONG, ZHANG HUA: "Ultrathin 2D Copper(I) 1,2,4‐Triazolate Coordination Polymer Nanosheets for Efficient and Selective Gene Silencing and Photodynamic Therapy", ADVANCED MATERIALS, VCH PUBLISHERS, DE, vol. 33, no. 18, 1 May 2021 (2021-05-01), DE , XP093077060, ISSN: 0935-9648, DOI: 10.1002/adma.202100849
ZHANG JIE-PENG, LIN YAN-YONG, HUANG XIAO-CHUN, CHEN XIAO-MING: "Copper(I) 1,2,4-Triazolates and Related Complexes: Studies of the Solvothermal Ligand Reactions, Network Topologies, and Photoluminescence Properties", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, vol. 127, no. 15, 1 April 2005 (2005-04-01), pages 5495 - 5506, XP093077064, ISSN: 0002-7863, DOI: 10.1021/ja042222t
Attorney, Agent or Firm:
JIAQUAN IP LAW (CN)
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