Title:
COPINE1 GENE MARKER FOR PROGNOSING METASTASIS OF HER2-POSITIVE BREAST CANCER AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/053887
Kind Code:
A1
Abstract:
This invention relates to a Copine1 gene marker for prognosing the metastasis of HER2-positive breast cancer and a use thereof. Specifically, the present invention relates to a biomarker composition for prognosing the metastasis of HER2-positive breast cancer, comprising Copine1 gene as an active ingredient, a composition for prognosing the metastasis of HER2-positive breast cancer, comprising an agent for measuring an mRNA or protein expression level of Copine1 gene, and a pharmaceutical composition for inhibiting the metastasis of HER2-positive breast cancer, comprising a Copine1 protein expression inhibitor as an active ingredient.
Inventors:
YOO JAE CHEAL (KR)
CHOI HYE YOUNG (KR)
WOO DONG KYUN (KR)
CHOI HYE YOUNG (KR)
WOO DONG KYUN (KR)
Application Number:
PCT/KR2023/012001
Publication Date:
March 14, 2024
Filing Date:
August 11, 2023
Export Citation:
Assignee:
NAT UNIV GYEONGSANG IACF (KR)
International Classes:
C12Q1/6886; A61K48/00; A61P35/00; G01N33/574
Domestic Patent References:
| WO2015049289A2 | 2015-04-09 | |||
| WO2013057323A2 | 2013-04-25 |
Foreign References:
| KR20180103024A | 2018-09-18 |
Other References:
SHAO ZHIHONG, MA XIAOLONG, ZHANG YUFENG, SUN YUANYUAN, LV WENJUAN, HE KUIGANG, XIA RUI, WANG PEIJUN, GAO XIAOLONG: "CPNE1 predicts poor prognosis and promotes tumorigenesis and radioresistance via the AKT singling pathway in triple‐negative breast cancer", MOLECULAR CARCINOGENESIS, JOHN WILEY & SONS, INC., US, vol. 59, no. 5, 1 May 2020 (2020-05-01), US , pages 533 - 544, XP093147401, ISSN: 0899-1987, DOI: 10.1002/mc.23177
ERIKO TOKUNAGA; YASUE KIMURA; EIJI OKI; NAOYUKI UEDA; MOTONORI FUTATSUGI; KOJIRO MASHINO; MANABU YAMAMOTO; MASAHIKO IKEBE; YOSHIHI: "Akt is frequently activated in HER2/neu‐positive breast cancers and associated with poor prognosis among hormone‐treated patients", INTERNATIONAL JOURNAL OF CANCER, JOHN WILEY & SONS, INC., US, vol. 118, no. 2, 27 July 2005 (2005-07-27), US , pages 284 - 289, XP071282666, ISSN: 0020-7136, DOI: 10.1002/ijc.21358
CHOI HYE YOUNG, LEE HYO JUNG, MOON KYOUNG MI, MOON DONG KYU, LEE SECHAN, PARK HYEWON, HONG JINPYO, PARK MI JUNG, WOO DONG KYUN, YO: "Up-regulation of CPNE1 Appears to Enhance Cancer Progression in HER2-positive and Luminal A Breast Cancer Cells", ANTICANCER RESEARCH, INTERNATIONAL INSTITUTE OF ANTICANCER RESEARCH, GR, vol. 42, no. 7, 1 July 2022 (2022-07-01), GR , pages 3445 - 3452, XP093147402, ISSN: 0250-7005, DOI: 10.21873/anticanres.15831
유재철 등. 결합 단백질을 이용한 코파인1의 유방암 증식조절 및 관련 신호전달 연구. 이공학 개인기초연구지원사업/학문균형발전지원사업 최종(결과)보고서. 2020, pp. 1-7 (YOO, Jae-Chul et al. Research of Copine1 with binding proteins in regulation about breast cancer proliferation and related signal pathway. Final (Result) Report of Individual Basic Science&Engineering Research Support Program/Balanced Academic Development Support Project.)
ERIKO TOKUNAGA; YASUE KIMURA; EIJI OKI; NAOYUKI UEDA; MOTONORI FUTATSUGI; KOJIRO MASHINO; MANABU YAMAMOTO; MASAHIKO IKEBE; YOSHIHI: "Akt is frequently activated in HER2/neu‐positive breast cancers and associated with poor prognosis among hormone‐treated patients", INTERNATIONAL JOURNAL OF CANCER, JOHN WILEY & SONS, INC., US, vol. 118, no. 2, 27 July 2005 (2005-07-27), US , pages 284 - 289, XP071282666, ISSN: 0020-7136, DOI: 10.1002/ijc.21358
CHOI HYE YOUNG, LEE HYO JUNG, MOON KYOUNG MI, MOON DONG KYU, LEE SECHAN, PARK HYEWON, HONG JINPYO, PARK MI JUNG, WOO DONG KYUN, YO: "Up-regulation of CPNE1 Appears to Enhance Cancer Progression in HER2-positive and Luminal A Breast Cancer Cells", ANTICANCER RESEARCH, INTERNATIONAL INSTITUTE OF ANTICANCER RESEARCH, GR, vol. 42, no. 7, 1 July 2022 (2022-07-01), GR , pages 3445 - 3452, XP093147402, ISSN: 0250-7005, DOI: 10.21873/anticanres.15831
유재철 등. 결합 단백질을 이용한 코파인1의 유방암 증식조절 및 관련 신호전달 연구. 이공학 개인기초연구지원사업/학문균형발전지원사업 최종(결과)보고서. 2020, pp. 1-7 (YOO, Jae-Chul et al. Research of Copine1 with binding proteins in regulation about breast cancer proliferation and related signal pathway. Final (Result) Report of Individual Basic Science&Engineering Research Support Program/Balanced Academic Development Support Project.)
Attorney, Agent or Firm:
CHOI, Kyu Whan (KR)
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