Title:
COPOLYMER AND APPLICATION THEREFOR
Document Type and Number:
WIPO Patent Application WO/2018/003821
Kind Code:
A1
Abstract:
Provided are: a copolymer having sufficient biocompatibility for use in medical material applications; and a method for forming a cross-linked body that uses said copolymer and imparts biocompatibility to a substrate surface. More specifically, a protein-absorption suppression effect and a cell-adhesion inhibition effect, being characteristics of phosphorylcholine groups, are imparted to the substrate surface. The present invention was completed as a result of the discovery that a copolymer containing a phosphorylcholine structural unit and a photoreactive structural unit or a copolymer containing a phosphorylcholine structural unit, a photoreactive structural unit, and a hydrophobic structural unit can impart a protein-absorption suppression effect and a cell-adhesion inhibition effect to a substrate surface by using a simple method called light irradiation.
Inventors:
ISHIHARA KAZUHIKO (JP)
MATSUDA MASARU (JP)
NODA TOMOZUMI (JP)
YAMADA SATOSHI (JP)
SAKAMOTO NOBUYUKI (JP)
MATSUDA MASARU (JP)
NODA TOMOZUMI (JP)
YAMADA SATOSHI (JP)
SAKAMOTO NOBUYUKI (JP)
Application Number:
PCT/JP2017/023654
Publication Date:
January 04, 2018
Filing Date:
June 28, 2017
Export Citation:
Assignee:
NOF CORP (JP)
UNIV TOKYO (JP)
UNIV TOKYO (JP)
International Classes:
C08F230/02; A61L33/06; C08J7/056; C09D143/02
Domestic Patent References:
| WO2017047680A1 | 2017-03-23 | |||
| WO2009066746A1 | 2009-05-28 |
Foreign References:
| JP2010059367A | 2010-03-18 | |||
| JP2010059346A | 2010-03-18 |
Other References:
TOMOHIRO KONNO ET AL.: "Photo-immobilization of a phospholipid polymer for surface modification", BIOMATERIALS, vol. 26, no. 12, April 2005 (2005-04-01), pages 1381 - 1388, XP027767754
NADIA POILANE ET AL.: "WELL DEFINED SURFACE PREPARATION WITH PHOSPHOLIPID POLYMERS FOR HIGHLY SENSITIVE IMMUNOASSAYS", THE 55TH SYMPOSIUM ON MACROMOLECULES YOKOSHU, vol. 55, no. 2, 5 September 2006 (2006-09-05)
NADIA POILANE ET AL.: "WELL DEFINED SURFACE PREPARATION WITH PHOSPHOLIPID POLYMERS FOR HIGHLY SENSITIVE IMMUNOASSAYS", THE 55TH SYMPOSIUM ON MACROMOLECULES YOKOSHU, vol. 55, no. 2, 5 September 2006 (2006-09-05)
Attorney, Agent or Firm:
SHOJI, Takashi et al. (JP)
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